各位同好大家好： 有一些文章不約而同的提到了類似的臨床試驗。這些臨床試驗的目的都是想要減輕 慢性的抗宿主反應。有一些細胞療法的成敗關鍵就在於病人能否度過抗宿主反應的 難關，所以找出減輕抗宿主反應的方法是很重要的，相信許多生技方面的同好兜會 有興趣。以下有幾篇這類臨床試驗所發表的paper，如果有興趣的話，不妨去看看： Cotransplantation of mesenchymal stem cells might prevent death from graft-versus-host disease (GVHD) without abrogating graft-versus-tumor effects after HLA-mismatched allogeneic transplantation following nonmyeloablative conditioning. Baron F, Lechanteur C, Willems E, Bruck F, Baudoux E, Seidel L, Vanbellinghen JF, Hafraoui K, Lejeune M, Gothot A, Fillet G, Beguin Y. Biol Blood Marrow Transplant. 2010 Jun;16(6):838-47. doi: 10.1016/j.bbmt.2010.01.011. Epub 2010 Jan 28. Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Ringdén O, Uzunel M, Rasmusson I, Remberger M, Sundberg B, Lönnies H, Marschall HU, Dlugosz A, Szakos A, Hassan Z, Omazic B, Aschan J, Barkholt L, Le Blanc K. Transplantation. 2006 May 27;81(10):1390-7. [Mesenchymal stem cells for treatment of steroid-resistant chronic graft-versus-host disease]. Zhang LS, Liu QF, Huang K, Zhang Y, Fan ZP, Huang SL. Zhonghua Nei Ke Za Zhi. 2009 Jul;48(7):542-6. Chinese Efficacy of bone marrow-derived mesenchymal stem cells in the treatment of sclerodermatous chronic graft-versus-host disease: clinical report. Zhou H, Guo M, Bian C, Sun Z, Yang Z, Zeng Y, Ai H, Zhao RC. Biol Blood Marrow Transplant. 2010 Mar;16(3):403-12. doi: 10.1016/j.bbmt.2009.11.006. Epub 2009 Nov 17. 網址： http://tinyurl.com/abvg62v http://tinyurl.com/a7b2jn3 如果大家有什麼評論，歡迎來信交流[email protected] [期刊網址/ 太長的話 請到http://tinyurl.com縮網址] --

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