各位同好大家好： 有一些文章不约而同的提到了类似的临床试验。这些临床试验的目的都是想要减轻 慢性的抗宿主反应。有一些细胞疗法的成败关键就在於病人能否度过抗宿主反应的 难关，所以找出减轻抗宿主反应的方法是很重要的，相信许多生技方面的同好兜会 有兴趣。以下有几篇这类临床试验所发表的paper，如果有兴趣的话，不妨去看看： Cotransplantation of mesenchymal stem cells might prevent death from graft-versus-host disease (GVHD) without abrogating graft-versus-tumor effects after HLA-mismatched allogeneic transplantation following nonmyeloablative conditioning. Baron F, Lechanteur C, Willems E, Bruck F, Baudoux E, Seidel L, Vanbellinghen JF, Hafraoui K, Lejeune M, Gothot A, Fillet G, Beguin Y. Biol Blood Marrow Transplant. 2010 Jun;16(6):838-47. doi: 10.1016/j.bbmt.2010.01.011. Epub 2010 Jan 28. Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Ringdén O, Uzunel M, Rasmusson I, Remberger M, Sundberg B, Lönnies H, Marschall HU, Dlugosz A, Szakos A, Hassan Z, Omazic B, Aschan J, Barkholt L, Le Blanc K. Transplantation. 2006 May 27;81(10):1390-7. [Mesenchymal stem cells for treatment of steroid-resistant chronic graft-versus-host disease]. Zhang LS, Liu QF, Huang K, Zhang Y, Fan ZP, Huang SL. Zhonghua Nei Ke Za Zhi. 2009 Jul;48(7):542-6. Chinese Efficacy of bone marrow-derived mesenchymal stem cells in the treatment of sclerodermatous chronic graft-versus-host disease: clinical report. Zhou H, Guo M, Bian C, Sun Z, Yang Z, Zeng Y, Ai H, Zhao RC. Biol Blood Marrow Transplant. 2010 Mar;16(3):403-12. doi: 10.1016/j.bbmt.2009.11.006. Epub 2009 Nov 17. 网址： http://tinyurl.com/abvg62v http://tinyurl.com/a7b2jn3 如果大家有什麽评论，欢迎来信交流[email protected] [期刊网址/ 太长的话 请到http://tinyurl.com缩网址] --

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