高醫醫學研究所與東京大學醫研科橫山一成客座教授與美國CITY OF HOPE機構 (http://www.cityofhope.org/Pages/default.aspx)進行研究合作，目前該機構提供補助 研習JDP2相關技術的機會，名額只有1名，期間3個月~1年不等，並補助機票費及研習期間 之生活費，歡迎有興趣者踴躍提出申請！ 有意申請者請檢附下列資料 1.申請意願書(中英文各一份,兩頁以內)，說明內容如下，請以A4紙書寫。 (1)申請目的 (2)個人研究專長 (3)預期效益 2.中英文簡歷 3.指導教授英文推薦信一封。 意者請聯絡黃先生 [email protected] Detail of applicants Applicants; Graduate student or Assistant professor (under 35). In the case of assistant professor, I wish to cooperate with the applicant about this JDP2 project for a long time in KMU after education in Keiichi’s laboratory, COH. Place: Beckman Research Institute of the City of Hope, Dept. of Molecular Biology Keiichi Itakura’s laboratory (1450 Duarte Road, Duarte, CA 91010, USA) Research period: 3 months to one year Experimental topics: Molecular biology of JDP2 transcription factor under the control of Keiichi Itakura and K. Yokoyama (References) 1.Jin, C., Li, H., Murata, T., Sun, K., Horikoshi, M., Chiu, R., and Yokoyama, K.: JDP-2, a repressor of AP-1, recruits a histone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 cells. Mol. Cell. Biol. 22, 4815-4826 (2002). 2.Jin, C., Kato, K., Chimura, T., Yamasaki, T., Nakade, K., Murata, T., Li, H., Pan, J., Zhao, M., Sun, K., Chiu, R., Ito, T., Nagata, K., Horikoshi, M., and Yokoyama, K.: Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2. Nature Structural & Molecular Biology 13, 331-338 (2006). 3.Nakade, K., Pan, J., Yoshiki, A., Ugai, H., Kimura, M., Liu, B., Li, H., Obata, Y., Iwama, M., Itohara, S., Murata, T., and Yokoyama, K.: JDP2 suppresses adipocyte differentiation by regulating histone acetylation. Cell Death and Differentiaton 14, 1398-1405 (2007). 4.Weidenfeld-Baranboim, K., Hasin, T., Darlyuk, I., Heinrich, R., Elhanami, O., Pan, J., Yokoyama, K., and Aronheim, A.: The ubiquitously expressed bZIP inhibitor, JDP2, suppresses the transcription of its homologue immediate early gene counterpart, ATF-3. Nucleic Acids Res. 37, 2194-2203 (2009). 5.Nakade, K., Pan, J., Yamasaki, T.,, Murata, T., Wasylyk, B., and Yokoyama, K.: Jun dimerization protein-2 deficient mouse embryonic fibroblasts are resistant to replicative senescence. J. Biol. Chem. 284. 10808-10817 (2009). K. Yokoyama’s laboratory HP: http://kazu.dlearn.kmu.edu.tw/ Coverage: Fly tickets and living fee in USA (with insurance and minimum requirement) After training: the applicants should be return to KMU and cooperate with K. Yokoyama about this JDP2 project. Materials: JDP2 KO mice, JDP2/p53 KO mice, JDP2 Tg mice,. JDP2 Cre mice, JDP2 ES cells, a series of point mutants of every JDP2 gene, recombinant adenovirus encoded JDP2 --

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