高医医学研究所与东京大学医研科横山一成客座教授与美国CITY OF HOPE机构 (http://www.cityofhope.org/Pages/default.aspx)进行研究合作，目前该机构提供补助 研习JDP2相关技术的机会，名额只有1名，期间3个月~1年不等，并补助机票费及研习期间 之生活费，欢迎有兴趣者踊跃提出申请！ 有意申请者请检附下列资料 1.申请意愿书(中英文各一份,两页以内)，说明内容如下，请以A4纸书写。 (1)申请目的 (2)个人研究专长 (3)预期效益 2.中英文简历 3.指导教授英文推荐信一封。 意者请联络黄先生 [email protected] Detail of applicants Applicants; Graduate student or Assistant professor (under 35). In the case of assistant professor, I wish to cooperate with the applicant about this JDP2 project for a long time in KMU after education in Keiichi’s laboratory, COH. Place: Beckman Research Institute of the City of Hope, Dept. of Molecular Biology Keiichi Itakura’s laboratory (1450 Duarte Road, Duarte, CA 91010, USA) Research period: 3 months to one year Experimental topics: Molecular biology of JDP2 transcription factor under the control of Keiichi Itakura and K. Yokoyama (References) 1.Jin, C., Li, H., Murata, T., Sun, K., Horikoshi, M., Chiu, R., and Yokoyama, K.: JDP-2, a repressor of AP-1, recruits a histone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 cells. Mol. Cell. Biol. 22, 4815-4826 (2002). 2.Jin, C., Kato, K., Chimura, T., Yamasaki, T., Nakade, K., Murata, T., Li, H., Pan, J., Zhao, M., Sun, K., Chiu, R., Ito, T., Nagata, K., Horikoshi, M., and Yokoyama, K.: Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2. Nature Structural & Molecular Biology 13, 331-338 (2006). 3.Nakade, K., Pan, J., Yoshiki, A., Ugai, H., Kimura, M., Liu, B., Li, H., Obata, Y., Iwama, M., Itohara, S., Murata, T., and Yokoyama, K.: JDP2 suppresses adipocyte differentiation by regulating histone acetylation. Cell Death and Differentiaton 14, 1398-1405 (2007). 4.Weidenfeld-Baranboim, K., Hasin, T., Darlyuk, I., Heinrich, R., Elhanami, O., Pan, J., Yokoyama, K., and Aronheim, A.: The ubiquitously expressed bZIP inhibitor, JDP2, suppresses the transcription of its homologue immediate early gene counterpart, ATF-3. Nucleic Acids Res. 37, 2194-2203 (2009). 5.Nakade, K., Pan, J., Yamasaki, T.,, Murata, T., Wasylyk, B., and Yokoyama, K.: Jun dimerization protein-2 deficient mouse embryonic fibroblasts are resistant to replicative senescence. J. Biol. Chem. 284. 10808-10817 (2009). K. Yokoyama’s laboratory HP: http://kazu.dlearn.kmu.edu.tw/ Coverage: Fly tickets and living fee in USA (with insurance and minimum requirement) After training: the applicants should be return to KMU and cooperate with K. Yokoyama about this JDP2 project. Materials: JDP2 KO mice, JDP2/p53 KO mice, JDP2 Tg mice,. JDP2 Cre mice, JDP2 ES cells, a series of point mutants of every JDP2 gene, recombinant adenovirus encoded JDP2 --

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