[標題]: The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis [內文]: 1. Nature, Vol. 427, 510~517 (2004) http://tinyurl.com/6sm7j 2. 摘要 Meiosis comprises a pair of specialized nuclear divisions that produce haploid germ cells. To accomplish this, sister chromatids must segregate together during the first meiotic division (meiosis I), which requires that sister chromatid cohesion persists at centromeres. The factors that protect centromeric cohesion during meiosis I have remained elusive. Here we identify Sgo1 (shugoshin), a protector of the centromeric cohesin Rec8 in fission yeast. We also identify a homologue of Sgo1 in budding yeast. We provide evidence that shugoshin is widely conserved among eukaryotes. Moreover, we identify Sgo2, a paralogue of shugosh in in fission yeast, which is required for faithful mitotic chromosome segregation. Localization of Sgo1 and Sgo2 at centromeres requires the kinase Bub1, identifying shugoshin as a crucial target for the kinetochore function of Bub1. These findings provide insights into the evolution of meiosis and kinetochore regulation during mitosis and meiosis. 中文：在減數分裂時，靠近centromere的Rec8 cohesin protein在 meiosis I不會被分解，所以一般認為應該有一個蛋白質在保護Rec8。 這篇主要是在講他們找到了一個蛋白質叫做Shudoshin(Sgo1)，會在 meiosis I的時候保護Rec8不被分解。以及這個蛋白質在細胞內的會 分布會受到kinetochore上的一個調節蛋白Bub1所影響。 3. 分享心得： 這是我在準備要報seminar的paper，以及我準備在這裡找個小問題， 讓我能提一個outfield proposal，如果有人也對這方面有興趣，歡迎 一起討論，或是幫我啦。(因為我本身不是做yeast的。) -- 等待.... 人的一生中有多少次的等待.... 錯過.... 人的一生中有多少次的錯過.... 等待與錯過.... 就像是 DNA double helix 的兩股一般.... --

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