[标题]: The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis [内文]: 1. Nature, Vol. 427, 510~517 (2004) http://tinyurl.com/6sm7j 2. 摘要 Meiosis comprises a pair of specialized nuclear divisions that produce haploid germ cells. To accomplish this, sister chromatids must segregate together during the first meiotic division (meiosis I), which requires that sister chromatid cohesion persists at centromeres. The factors that protect centromeric cohesion during meiosis I have remained elusive. Here we identify Sgo1 (shugoshin), a protector of the centromeric cohesin Rec8 in fission yeast. We also identify a homologue of Sgo1 in budding yeast. We provide evidence that shugoshin is widely conserved among eukaryotes. Moreover, we identify Sgo2, a paralogue of shugosh in in fission yeast, which is required for faithful mitotic chromosome segregation. Localization of Sgo1 and Sgo2 at centromeres requires the kinase Bub1, identifying shugoshin as a crucial target for the kinetochore function of Bub1. These findings provide insights into the evolution of meiosis and kinetochore regulation during mitosis and meiosis. 中文：在减数分裂时，靠近centromere的Rec8 cohesin protein在 meiosis I不会被分解，所以一般认为应该有一个蛋白质在保护Rec8。 这篇主要是在讲他们找到了一个蛋白质叫做Shudoshin(Sgo1)，会在 meiosis I的时候保护Rec8不被分解。以及这个蛋白质在细胞内的会 分布会受到kinetochore上的一个调节蛋白Bub1所影响。 3. 分享心得： 这是我在准备要报seminar的paper，以及我准备在这里找个小问题， 让我能提一个outfield proposal，如果有人也对这方面有兴趣，欢迎 一起讨论，或是帮我啦。(因为我本身不是做yeast的。) -- 等待.... 人的一生中有多少次的等待.... 错过.... 人的一生中有多少次的错过.... 等待与错过.... 就像是 DNA double helix 的两股一般.... --

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