想请大家帮我看一下这样翻译对不对 Cell death triggered by synthetic flavonoids in human leukemia cells is amplified by the inhibition of extracellular signal-regulated kinase signaling 藉由抑制细胞外信号调节梅之信号， 可使类黄酮化合物在人类血癌细胞处发细胞死亡的效果放大。 A new class of methyl esters of flavonoids, with different substituents on the B ring were synthesized and evaluated for their antiproliferative activity against the human leukemia cell line HL-60. The presence of either a methyl group (1f) or a chlorine atom (1o) at position 20 of the B ring played an important role in affecting antiproliferative activity. The cytotoxic effects of these compounds were accompanied by the concentration- and time-dependent appearance of DNA- and nuclear-fragmentation, increase in the percentage of sub-G1 cells, and processing of multiple caspases and poly(ADP-ribose)polymerase cleavage. Pretreatment of cells with the specific mitogen-activated extracellular kinases (MEK) 1/2 inhibitor PD98059, together with 1f and 1o, resulted in an important enhancement of cell death, which might have clinical implications for the use of both compounds in combination with MEK 1/2 inhibitors as potential therapeutic agents. 我们合成一系列不同B环的类黄酮甲基酯化合物并评估他们对於人类血癌细胞株HL-60的 抗生殖效果。结果显示在B环的2号位接上甲基和氯可在此细胞株抗生殖上发挥效果。 这些化合物的细胞毒性受到一些浓度 时间相关的DNA片段影响，增加了sub-G1细胞所占 的百分比并使一些蛋白脢及聚合酶分解。 将细胞预先以特定的(MEK) 1/2的抑制剂PD98059处理，将大大增加此类黄酮化合物的效果 ，这将在临床上使类黄酮化合物结合(MEK) 1/2的抑制剂成为一个有治疗潜力的药剂。 麻烦大家帮我看一下我翻的对不会 或是有哪些需要加强的地方~~ --

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