幫宣傳~ 我們實驗室在Max-Planck Institute for Experimental Medicine 位於德國中北部一個叫哥廷根(Goettingen)的大學城 這是實驗室department的網頁 http://www.em.mpg.de/index.php?id=33&L=1&tx_jppageteaser_pi1[backId]=16 我的小老闆（日本人）在這個department當group leader 最近通過了幾個計畫有錢所以想收博士生 我目前在跟他做碩士，三月底交完碩士論文後會繼續做PhD 組上另有兩個PhD學生，但今年會相繼畢業 他對台灣學生的印象不錯 因此拜託我做宣傳，希望可以徵到有實力跟熱忱的學生 以下是我小老闆提供的資訊，有興趣者（具生物相關碩士學位）可直接寄CV給他 若他對你有興趣會先請你用Skype面試（英文） 有問題可寄站內信給我~ Advisor: Hiroshi Kawabe We are recruiting excellent and highly motivated PhD students. Currently, two PhD student positions are available. The salary will be supported during their PhD courses. Project: Ubiquitination is a key regulatory step for neuronal functions, including circuit formation, synaptogenesis, and synaptic transmission. Ubiquitination of target molecules is mediated by 3 classes of enzymes, E1 ubiquitin activating enzymes, E2 ubiquitin conjugating enzymes, and E3 ubiquitin ligases. E3 ubiquitin ligases determine the substrate specificity and, in some cases, the polyubiquitin chain type specificity. The research of our team has been focused on functional analysis of HECT type E3 ligases in the brain. We have established conditional knockout mouse lines for several Nedd4 family HECT type ligases. Using one of these lines, we reported recently that Nedd4-1 is a critical regulator of morphogenesis of the dendrite (Kawabe et al., Neuron, 65, 358, 2010) and already found other phenotypes in our mutant mouse lines. We will further characterize these mouse lines and identifying the physiological target proteins of these E3 ligases. The ultimate goals of our projects are to understand roles of specific ubiquitination pathways in regulation of brain function and development. Contact: [email protected] --

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