帮宣传~ 我们实验室在Max-Planck Institute for Experimental Medicine 位於德国中北部一个叫哥廷根(Goettingen)的大学城 这是实验室department的网页 http://www.em.mpg.de/index.php?id=33&L=1&tx_jppageteaser_pi1[backId]=16 我的小老板（日本人）在这个department当group leader 最近通过了几个计画有钱所以想收博士生 我目前在跟他做硕士，三月底交完硕士论文後会继续做PhD 组上另有两个PhD学生，但今年会相继毕业 他对台湾学生的印象不错 因此拜托我做宣传，希望可以徵到有实力跟热忱的学生 以下是我小老板提供的资讯，有兴趣者（具生物相关硕士学位）可直接寄CV给他 若他对你有兴趣会先请你用Skype面试（英文） 有问题可寄站内信给我~ Advisor: Hiroshi Kawabe We are recruiting excellent and highly motivated PhD students. Currently, two PhD student positions are available. The salary will be supported during their PhD courses. Project: Ubiquitination is a key regulatory step for neuronal functions, including circuit formation, synaptogenesis, and synaptic transmission. Ubiquitination of target molecules is mediated by 3 classes of enzymes, E1 ubiquitin activating enzymes, E2 ubiquitin conjugating enzymes, and E3 ubiquitin ligases. E3 ubiquitin ligases determine the substrate specificity and, in some cases, the polyubiquitin chain type specificity. The research of our team has been focused on functional analysis of HECT type E3 ligases in the brain. We have established conditional knockout mouse lines for several Nedd4 family HECT type ligases. Using one of these lines, we reported recently that Nedd4-1 is a critical regulator of morphogenesis of the dendrite (Kawabe et al., Neuron, 65, 358, 2010) and already found other phenotypes in our mutant mouse lines. We will further characterize these mouse lines and identifying the physiological target proteins of these E3 ligases. The ultimate goals of our projects are to understand roles of specific ubiquitination pathways in regulation of brain function and development. Contact: [email protected] --

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