※ 引述《bragihsu (布拉吉)》之銘言： : 以ABP第332～333頁的說法 : First-Pass Effects : For some drugs, the route of administration affects the metabolic rate of the : compound. For example, a drug given parenterally, transdermally, or by : inhalation may distribute within the body prior to metabolism by the liver. : In contrast, drugs given orally are normally absorbed in the duodenal segment : of the small intestine and transported via the mesenteric vessels to the : hepatic portal vein and then to the liver before entering the systemic : circulation. Drugs that are highly metabolized by the liver or by the : intestinal mucosal cells demonstrate poor systemic availability when given : orally. This rapid metabolism of an orally administered drug before reaching : the general circulation is termed first-pass effect or presystemic : elimination. : ABP這本書是把first-pass effect 和 presystemic elimination當做是一樣的。 : 不過以題目上來說，真的硬要區別的話，我同意W大的說法和S大的補充。 : 排除elimination是指物質從體內消失，包含代謝metabolism與排泄excretion的，是 : 更為廣義的。 : 此外，first-pass effect除了會發生在肝臟以外，在腸道及腸細胞裡也可能會發生的。 口服藥物進入循環系統之前，將其排除之作用，下列何者正確？ (A)gastrointestinal elimination(B)presystemic elimination (C)first-pass effect(D)peritoneal dialysis 如果是要針對口服藥物未進入循環前,藥毒物於腸道的代謝排除 就這題而言,(A)gastrointestinal elimination答案不是比(B)或(C)更好嗎? --

※ 發信站: 批踢踢實業坊(ptt.cc) ◆ From: 58.115.146.60 哇哈哈~我承認我有點鑽牛角尖 所以sugarli大大,還是認為題目跟答案沒有錯誤嗎~^^? ※ 編輯: pig0210 來自: 58.115.146.60 (07/17 20:30) 真是中文腦力激盪了好幾回 不過真的很謝謝你們大家,讓我稍微了解(A)(B)(C)三者的差異~...^///^ ※ 編輯: pig0210 來自: 58.115.146.60 (07/17 20:35)