※ 引述《bragihsu (布拉吉)》之铭言： : 以ABP第332～333页的说法 : First-Pass Effects : For some drugs, the route of administration affects the metabolic rate of the : compound. For example, a drug given parenterally, transdermally, or by : inhalation may distribute within the body prior to metabolism by the liver. : In contrast, drugs given orally are normally absorbed in the duodenal segment : of the small intestine and transported via the mesenteric vessels to the : hepatic portal vein and then to the liver before entering the systemic : circulation. Drugs that are highly metabolized by the liver or by the : intestinal mucosal cells demonstrate poor systemic availability when given : orally. This rapid metabolism of an orally administered drug before reaching : the general circulation is termed first-pass effect or presystemic : elimination. : ABP这本书是把first-pass effect 和 presystemic elimination当做是一样的。 : 不过以题目上来说，真的硬要区别的话，我同意W大的说法和S大的补充。 : 排除elimination是指物质从体内消失，包含代谢metabolism与排泄excretion的，是 : 更为广义的。 : 此外，first-pass effect除了会发生在肝脏以外，在肠道及肠细胞里也可能会发生的。 口服药物进入循环系统之前，将其排除之作用，下列何者正确？ (A)gastrointestinal elimination(B)presystemic elimination (C)first-pass effect(D)peritoneal dialysis 如果是要针对口服药物未进入循环前,药毒物於肠道的代谢排除 就这题而言,(A)gastrointestinal elimination答案不是比(B)或(C)更好吗? --

※ 发信站: 批踢踢实业坊(ptt.cc) ◆ From: 58.115.146.60 哇哈哈~我承认我有点钻牛角尖 所以sugarli大大,还是认为题目跟答案没有错误吗~^^? ※ 编辑: pig0210 来自: 58.115.146.60 (07/17 20:30) 真是中文脑力激荡了好几回 不过真的很谢谢你们大家,让我稍微了解(A)(B)(C)三者的差异~...^///^ ※ 编辑: pig0210 来自: 58.115.146.60 (07/17 20:35)