節錄Metformin for treatment of the polycystic ovary syndrome（UpToDate） Dose — Metformin is available in a generic form as 500, 850, and 1000 mg tablets. The target dose is 1500 to 2550 mg; clinically significant responses are not regularly observed at doses less than 1000 mg daily. Many clinicians begin treatment with 500 mg taken with a large meal, to reduce gastrointestinal side effects. If tolerated, the dose can be increased to 500 mg at both lunch and dinner, and then to 500 mg at breakfast, lunch, and dinner. 另外在Dose and side effects 中也有寫 The two best studied metformin regimens are 500 mg three times daily (1500 mg daily) and 850 mg twice daily (1700 mg daily).Some authorities believe that women with PCOS who do not respond at these doses should be treated with 2000 mg daily （Medline ® Abstract for Reference 39 of 'Metformin for treatment of the polycystic ovary syndrome' ） 所以依照這樣看的話，開TID應該是沒有問題的＠＠a 但不知道資料是否正確，如有錯誤希望前輩可以指教 謝謝 -- 我之前是吃500mg BID ，但吃了半年後就沒什麼成效了...~"~ -- 。 //* 請叫我偉大的西施女王Kitty大小姐喔呵呵呵～＊ ┌ ╭─┤╭─╮╭─╮╭─╮╭─╮╭┬╮╭ ╮╭─╮╭─┤ ┐ │ │ ││ ││ ││ ││╭╮│││││││ ││ │ │ └ ╰─╯╰─╰╰ ╯╰─╰╰─╯╰ ╯╰┴╯╰─╰╰─╯ ┘⊿ >///< --

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