节录Metformin for treatment of the polycystic ovary syndrome（UpToDate） Dose — Metformin is available in a generic form as 500, 850, and 1000 mg tablets. The target dose is 1500 to 2550 mg; clinically significant responses are not regularly observed at doses less than 1000 mg daily. Many clinicians begin treatment with 500 mg taken with a large meal, to reduce gastrointestinal side effects. If tolerated, the dose can be increased to 500 mg at both lunch and dinner, and then to 500 mg at breakfast, lunch, and dinner. 另外在Dose and side effects 中也有写 The two best studied metformin regimens are 500 mg three times daily (1500 mg daily) and 850 mg twice daily (1700 mg daily).Some authorities believe that women with PCOS who do not respond at these doses should be treated with 2000 mg daily （Medline ® Abstract for Reference 39 of 'Metformin for treatment of the polycystic ovary syndrome' ） 所以依照这样看的话，开TID应该是没有问题的＠＠a 但不知道资料是否正确，如有错误希望前辈可以指教 谢谢 -- 我之前是吃500mg BID ，但吃了半年後就没什麽成效了...~"~ -- 。 //* 请叫我伟大的西施女王Kitty大小姐喔呵呵呵～＊ ┌ ╭─┤╭─╮╭─╮╭─╮╭─╮╭┬╮╭ ╮╭─╮╭─┤ ┐ │ │ ││ ││ ││ ││╭╮│││││││ ││ │ │ └ ╰─╯╰─╰╰ ╯╰─╰╰─╯╰ ╯╰┴╯╰─╰╰─╯ ┘⊿ >///< --

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