作者PHM (自信而不自負)
看板Pharmacy
標題Re: [問題] ISA-β blocker不能用在angina的原因？？
時間Wed Feb 13 14:44:41 2008
※ 引述《premire (熱騰騰的泡麵)》之銘言：
: 關於這個問題一直存在 後來翻了Pharmacotherapy Handbook 第六版
: 後發現內文以下（翻中）：
: "ISA會將HR的reduction minimized, 因此limiting a reduction in MVO2"
: 有人可以跟我解釋這段的意思嗎？感覺α的活性和HR無關呀..
我參考完整版的p.280：
....intrinsic sympathomimetic activity appears to be detrimental in rest
or severe angina because the reduction in heart rate would be minimized,....
by eMedicine
Intrinsic sympathomimetic activity:
Some beta-blockers, such as pindolol and acebutolol, also have beta-agonist
properties. While their agonist property is weaker than that of
catecholamines, they are capable of stimulating beta-receptors, especially
when catecholamine levels are low. These agents are said to have intrinsic
sympathomimetic activity; this agonist property is protective in overdoses
所謂的ISA (intrinsic sympathomimetic activity)是指partial beta-agonist
所以會增加HR，應該不是跟alpha有關
--
※ 發信站: 批踢踢實業坊(ptt.cc)
◆ From: 140.116.93.132
1F：推 premire:原來和alpha無關,謝謝大家的解答 02/13 18:07
2F：推 outcastt:果然一看完整版就解決了 04/13 20:51