作者PHM (自信而不自负)
看板Pharmacy
标题Re: [问题] ISA-β blocker不能用在angina的原因？？
时间Wed Feb 13 14:44:41 2008
※ 引述《premire (热腾腾的泡面)》之铭言：
: 关於这个问题一直存在 後来翻了Pharmacotherapy Handbook 第六版
: 後发现内文以下（翻中）：
: "ISA会将HR的reduction minimized, 因此limiting a reduction in MVO2"
: 有人可以跟我解释这段的意思吗？感觉α的活性和HR无关呀..
我参考完整版的p.280：
....intrinsic sympathomimetic activity appears to be detrimental in rest
or severe angina because the reduction in heart rate would be minimized,....
by eMedicine
Intrinsic sympathomimetic activity:
Some beta-blockers, such as pindolol and acebutolol, also have beta-agonist
properties. While their agonist property is weaker than that of
catecholamines, they are capable of stimulating beta-receptors, especially
when catecholamine levels are low. These agents are said to have intrinsic
sympathomimetic activity; this agonist property is protective in overdoses
所谓的ISA (intrinsic sympathomimetic activity)是指partial beta-agonist
所以会增加HR，应该不是跟alpha有关
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1F：推 premire:原来和alpha无关,谢谢大家的解答 02/13 18:07
2F：推 outcastt:果然一看完整版就解决了 04/13 20:51