※ 引述《peter3752001 (手黑的腳白佑)》之銘言： : 讀季瑋珠老師的那份講義 : 有些問題 : 請知道的同學或路過的學長姐 : 幫忙解惑吧 : 衛導不好念,但是要普救世人 : 就要咬牙撐過去啊~~~(感冒中,喉嚨痛) : 1.P.2中間左邊那張ppt : literature retrieval and exclusion criteria是什麼意思? : 2.P.4中間右邊那張"基本設計"的對照組 : 下面寫說跟個案對照方法的對照不同 : 是哪裡不同? 我覺得啦～好像是...個案對照就像是老師講義上舉的例子：某人服用一帖XX丸的例子 只是個案 不代表XX丸用在別人身上就有用 而經由實驗設計則可以明確得知XX丸是否真的有用 我也不確定.所以如過錯的話請大家指正 : 3.同上頁右下 依照時間 : 同時是怎麼對照? : 歷史又是怎麼對照? 我在網路上找到的資料...可以參考一下啦 雖然是英文的 但我覺得他解釋得滿清楚的 historical control: The results of treatment with the test drug are compared with experience historically derived from the adequately documented natural history of the disease or condition, or from the results of active treatment, in comparable patients or populations. Because historical control populations usually cannot be as well assessed with respect to pertinent variables as can concurrent control populations, historical control designs are usually reserved for special circumstances. Examples include studies of diseases with high and predictable mortality (for example, certain malignancies) and studies in which the effect of the drug is self-evident (general anesthetics, drug metabolism). : 4.P.5左下 : 納入跟排除條件在說什麼? Inclusion and exclusion criteria are a means of establishing precision in your cohort or case-control study. For example, you might suspect that a new brand of insulin tablet is more effective than an existing brand, but for some reason this seems to be true only for diabetic patients that are not overweight by more than 10%. Your professional knowledge has produced a "hunch" that has you well on your way to establishing inclusion and exclusion criteria. Inclusion criteria are the criteria for including a patient in the study, and it is important that these criteria be clearly defined in an objective manner, so that anyone involved in the study (or anyone attempting to replicate the study) can reproduce patient inclusion decisions precisely. In other words, can you write down the inclusion criteria so that anyone else with professional knowledge similar to your own would include the same patients you included? The example above, of the new insulin tablet versus an existing one, could be translated into an inclusion criteria by specifying the two drugs (e.g. brand name, generic and manufacturer name, possibly even lot number). Exclusion criteria are the criteria for excluding patients from the study. From the example above, the 10% overweight criterion could serve as the basis for a specific exclusion criteria statement. As in the case of inclusion criteria, is your specification precise enough that someone with knowledge similar to your own would exclude the same patients you choose to exclude? : 5.P.6右上 : 事件是最終的終點 : 二分法則是叫硬性終點 : 所以事件不等於硬性終點吧(是二分法才是)? : 6.同上張 : 設限資料跟存活分析是什麼? : (雖然不會考這麼細,但是可不可以稍微講一下) : 7.Basic approaches是在講什麼的方法? : 8.P.7右上 : 何謂干擾因素? : 為什麼說結果比流行病學研究可信? : (那現在說的是什麼方法在跟流行病學研究比?) : 9.同上頁中間左邊那張 : 為什麼加入時間就變存活分析? : 10.同上頁左下 : Marginal是什麼意思? : 11.P.8右上 : 非標準實驗方法又稱準實驗方法??? : 12.P.9 : 實驗方法有很多種而藥物臨床試驗只是其中一種,對嗎? : 實驗方法等不等於實驗流行病學? : 問題頗多發現自己好像讀太細了~ : 捉不到重點啊~ 你真的讀的很細！！讓我發現自己很多地方都沒看清楚... 呵呵～大家加油！！ -- --

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