※ 引述《peter3752001 (手黑的脚白佑)》之铭言： : 读季玮珠老师的那份讲义 : 有些问题 : 请知道的同学或路过的学长姐 : 帮忙解惑吧 : 卫导不好念,但是要普救世人 : 就要咬牙撑过去啊~~~(感冒中,喉咙痛) : 1.P.2中间左边那张ppt : literature retrieval and exclusion criteria是什麽意思? : 2.P.4中间右边那张"基本设计"的对照组 : 下面写说跟个案对照方法的对照不同 : 是哪里不同? 我觉得啦～好像是...个案对照就像是老师讲义上举的例子：某人服用一帖XX丸的例子 只是个案 不代表XX丸用在别人身上就有用 而经由实验设计则可以明确得知XX丸是否真的有用 我也不确定.所以如过错的话请大家指正 : 3.同上页右下 依照时间 : 同时是怎麽对照? : 历史又是怎麽对照? 我在网路上找到的资料...可以参考一下啦 虽然是英文的 但我觉得他解释得满清楚的 historical control: The results of treatment with the test drug are compared with experience historically derived from the adequately documented natural history of the disease or condition, or from the results of active treatment, in comparable patients or populations. Because historical control populations usually cannot be as well assessed with respect to pertinent variables as can concurrent control populations, historical control designs are usually reserved for special circumstances. Examples include studies of diseases with high and predictable mortality (for example, certain malignancies) and studies in which the effect of the drug is self-evident (general anesthetics, drug metabolism). : 4.P.5左下 : 纳入跟排除条件在说什麽? Inclusion and exclusion criteria are a means of establishing precision in your cohort or case-control study. For example, you might suspect that a new brand of insulin tablet is more effective than an existing brand, but for some reason this seems to be true only for diabetic patients that are not overweight by more than 10%. Your professional knowledge has produced a "hunch" that has you well on your way to establishing inclusion and exclusion criteria. Inclusion criteria are the criteria for including a patient in the study, and it is important that these criteria be clearly defined in an objective manner, so that anyone involved in the study (or anyone attempting to replicate the study) can reproduce patient inclusion decisions precisely. In other words, can you write down the inclusion criteria so that anyone else with professional knowledge similar to your own would include the same patients you included? The example above, of the new insulin tablet versus an existing one, could be translated into an inclusion criteria by specifying the two drugs (e.g. brand name, generic and manufacturer name, possibly even lot number). Exclusion criteria are the criteria for excluding patients from the study. From the example above, the 10% overweight criterion could serve as the basis for a specific exclusion criteria statement. As in the case of inclusion criteria, is your specification precise enough that someone with knowledge similar to your own would exclude the same patients you choose to exclude? : 5.P.6右上 : 事件是最终的终点 : 二分法则是叫硬性终点 : 所以事件不等於硬性终点吧(是二分法才是)? : 6.同上张 : 设限资料跟存活分析是什麽? : (虽然不会考这麽细,但是可不可以稍微讲一下) : 7.Basic approaches是在讲什麽的方法? : 8.P.7右上 : 何谓干扰因素? : 为什麽说结果比流行病学研究可信? : (那现在说的是什麽方法在跟流行病学研究比?) : 9.同上页中间左边那张 : 为什麽加入时间就变存活分析? : 10.同上页左下 : Marginal是什麽意思? : 11.P.8右上 : 非标准实验方法又称准实验方法??? : 12.P.9 : 实验方法有很多种而药物临床试验只是其中一种,对吗? : 实验方法等不等於实验流行病学? : 问题颇多发现自己好像读太细了~ : 捉不到重点啊~ 你真的读的很细！！让我发现自己很多地方都没看清楚... 呵呵～大家加油！！ -- --

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