課程名稱︰訊息傳遞與疾病 課程性質︰選修 課程教師︰主授陳青周（此範圍為陳青周/李建國/蔡丰喬老師授課） 開課學院：醫學院 開課系所︰醫衛共同課程 考試日期（年月日）︰2017/06/09 考試時限（分鐘）：110分鐘 試題 : (以下敘述均非與原題目完全相同，僅就考試主題作最接近之題目描述) 陳青周老師part：佔45分 (範圍：NF-κB and Ubiquitination; Epigenetic mechanisms; Targeting transduction pathways for research and medical intervention) 問答題： 1. Please describe two examples of epigenetic drugs. Detail their functions and the mechanisms. (10%) 2. What is bivalent histone methylation? (5%) 3. Describe the process of ubiquitination: use IκBα as example. (15%) 4. Targeting growth factor signaling pathway, choose one example of monoclonal antibody drug and one example of small drug and detail their modes of actions. (15%) ---------- 李建國老師part：佔45分 (範圍：Signaling in Immune System: innate & adaptive immunity; Apoptosis) 問答題： 1. (1) Immunosuppressive drugs have been widely used in treating immune disease. Please describe two examples of immune diseases that need to be treated with drugs. (4%) (2) Please list two immunosuppressive drugs and detail their functions in the diseases. (8%) 2. (1) Innate immunity and adaptive immunity are two important arms of immune system. Please compare the differences of antigen receptors between these two systems. (6%) (2) Also, please explain the reasons why the innate immunity functions first and adaptive immunity later from the angle of signal transduction. (6%) (3) NF-κB is an important signaling pathway in the immune system. Please explain how NF-κB is activated by IKK complex. (6%) 3. (1) Apoptosis is an important mechanism in both cell physiology and pathology. Please describe two examples of apoptosis that occur in immune system. (6%) (2) In addition to apoptosis, there are other kinds of non-apoptotic cell deaths. Dr. Lee has recently discovered a new drug that will target tumor cells but not normal cells. Please tell Dr. Lee how to distinguish whether the cell is undergoing apoptosis or non-apoptotic cell death. (5%) (3) If the tumor cell is known to undergo apoptosis, then how to distinguish whether it uses intrinsic or extrinsic pathways? (4%) Please describe the two comparisons as thorough as possible. ---------- 蔡丰喬老師part：佔15分 (範圍：Cell adhesion) 一、選擇題：1題，共2分，問下列何者敘述錯誤 1. 敘述錯誤為 "Integrins often bind to their partners in homophilic patterns." 二、是非題：3題，各1分，題幹敘述正確者2題，錯誤1題 3. 敘述錯誤為 "In addition to β-catenin, tight junction proteins can also act as the receptors of Coxsackievirus." 三、簡答題：共10分 1. Please list three molecules of Cadherin and Wnt signaling that impress you the most. Why? (6%) 2. Please list two features of integrin signaling that impress you the most. Why? (4%) ＊ 簡答題題目均附有以下三點說明： (The item and reason will be one score respectively.) (Please restrict your answers in two lines. The answers outside the two lines will not be scored.) (You can give any examples including but not limited to the structures, functions, regulations, possible therapies or related drugs) ---------- 以上總分共計105分 --

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