课程名称︰讯息传递与疾病 课程性质︰选修 课程教师︰主授陈青周（此范围为陈青周/李建国/蔡丰乔老师授课） 开课学院：医学院 开课系所︰医卫共同课程 考试日期（年月日）︰2017/06/09 考试时限（分钟）：110分钟 试题 : (以下叙述均非与原题目完全相同，仅就考试主题作最接近之题目描述) 陈青周老师part：占45分 (范围：NF-κB and Ubiquitination; Epigenetic mechanisms; Targeting transduction pathways for research and medical intervention) 问答题： 1. Please describe two examples of epigenetic drugs. Detail their functions and the mechanisms. (10%) 2. What is bivalent histone methylation? (5%) 3. Describe the process of ubiquitination: use IκBα as example. (15%) 4. Targeting growth factor signaling pathway, choose one example of monoclonal antibody drug and one example of small drug and detail their modes of actions. (15%) ---------- 李建国老师part：占45分 (范围：Signaling in Immune System: innate & adaptive immunity; Apoptosis) 问答题： 1. (1) Immunosuppressive drugs have been widely used in treating immune disease. Please describe two examples of immune diseases that need to be treated with drugs. (4%) (2) Please list two immunosuppressive drugs and detail their functions in the diseases. (8%) 2. (1) Innate immunity and adaptive immunity are two important arms of immune system. Please compare the differences of antigen receptors between these two systems. (6%) (2) Also, please explain the reasons why the innate immunity functions first and adaptive immunity later from the angle of signal transduction. (6%) (3) NF-κB is an important signaling pathway in the immune system. Please explain how NF-κB is activated by IKK complex. (6%) 3. (1) Apoptosis is an important mechanism in both cell physiology and pathology. Please describe two examples of apoptosis that occur in immune system. (6%) (2) In addition to apoptosis, there are other kinds of non-apoptotic cell deaths. Dr. Lee has recently discovered a new drug that will target tumor cells but not normal cells. Please tell Dr. Lee how to distinguish whether the cell is undergoing apoptosis or non-apoptotic cell death. (5%) (3) If the tumor cell is known to undergo apoptosis, then how to distinguish whether it uses intrinsic or extrinsic pathways? (4%) Please describe the two comparisons as thorough as possible. ---------- 蔡丰乔老师part：占15分 (范围：Cell adhesion) 一、选择题：1题，共2分，问下列何者叙述错误 1. 叙述错误为 "Integrins often bind to their partners in homophilic patterns." 二、是非题：3题，各1分，题干叙述正确者2题，错误1题 3. 叙述错误为 "In addition to β-catenin, tight junction proteins can also act as the receptors of Coxsackievirus." 三、简答题：共10分 1. Please list three molecules of Cadherin and Wnt signaling that impress you the most. Why? (6%) 2. Please list two features of integrin signaling that impress you the most. Why? (4%) ＊ 简答题题目均附有以下三点说明： (The item and reason will be one score respectively.) (Please restrict your answers in two lines. The answers outside the two lines will not be scored.) (You can give any examples including but not limited to the structures, functions, regulations, possible therapies or related drugs) ---------- 以上总分共计105分 --

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