課程名稱︰分子生物學 課程性質︰必修 課程教師︰主授張麗冠（此範圍為王愛玉/黃楓婷老師授課） 開課學院：生命科學院 開課系所︰生化科技學系 考試日期（年月日）︰2016/11/07 考試時限（分鐘）：120分鐘 試題 : （以下為本學期第二次期中考，由王愛玉老師與黃楓婷老師共同出題） 考試範圍：Ch 10~12 The Mutability and Repair of DNA Homologous Recombination at the Molecular Level Site-Specific Recombination and Transposition of DNA 王老師部分：佔50% （事先公布試題，考試當天不得帶大抄） 有些疾病已知與DNA repair system無法正常運作有關。 請搜尋文獻，找出任五種與DNA repair缺失相關的疾病。 每種疾病10分，每一種疾病皆需敘述： 1) 此疾病的名稱及主要特徵 （2分） 2) 是導因於哪一種（或哪些）DNA repair system 發生問題？（寫出名稱即可）（2分） 3) 此 DNA repair system 正常機制為何？造成疾病的關鍵點為何？（6分） 黃老師部分：佔51% 1. In cells, what will be the effect if meiotic recombination does not occur? (3%) 2. Please describe the six biological functions of homologous recombination. (6%) 3. Please describe the differences between HR and CSSR. (Hint: Where? How?) (6%) 4. Please describe and draw the three different types of site-specific recombination. (6%) 5. Gene conversion usually occurs in different organisms with different mechanisms. Please describe two types of gene conversion in detail. (Hint: in HR and CSSR) (8%) 6. Transposition is carefully regulated in organisms to protect the chromosome integrity. Please describe two types of mechanisms that transposition is regulated, each with an example to illustrate in detail. (10%) 7. Please describe each step of the homologous recombination and write down the proteins mainly responsible for each step in RecBCD pathway. (12%) --

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