课程名称︰分子生物学 课程性质︰必修 课程教师︰主授张丽冠（此范围为王爱玉/黄枫婷老师授课） 开课学院：生命科学院 开课系所︰生化科技学系 考试日期（年月日）︰2016/11/07 考试时限（分钟）：120分钟 试题 : （以下为本学期第二次期中考，由王爱玉老师与黄枫婷老师共同出题） 考试范围：Ch 10~12 The Mutability and Repair of DNA Homologous Recombination at the Molecular Level Site-Specific Recombination and Transposition of DNA 王老师部分：占50% （事先公布试题，考试当天不得带大抄） 有些疾病已知与DNA repair system无法正常运作有关。 请搜寻文献，找出任五种与DNA repair缺失相关的疾病。 每种疾病10分，每一种疾病皆需叙述： 1) 此疾病的名称及主要特徵 （2分） 2) 是导因於哪一种（或哪些）DNA repair system 发生问题？（写出名称即可）（2分） 3) 此 DNA repair system 正常机制为何？造成疾病的关键点为何？（6分） 黄老师部分：占51% 1. In cells, what will be the effect if meiotic recombination does not occur? (3%) 2. Please describe the six biological functions of homologous recombination. (6%) 3. Please describe the differences between HR and CSSR. (Hint: Where? How?) (6%) 4. Please describe and draw the three different types of site-specific recombination. (6%) 5. Gene conversion usually occurs in different organisms with different mechanisms. Please describe two types of gene conversion in detail. (Hint: in HR and CSSR) (8%) 6. Transposition is carefully regulated in organisms to protect the chromosome integrity. Please describe two types of mechanisms that transposition is regulated, each with an example to illustrate in detail. (10%) 7. Please describe each step of the homologous recombination and write down the proteins mainly responsible for each step in RecBCD pathway. (12%) --

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