課程名稱︰環境與職業毒理學概論 課程性質︰領域必修 課程教師︰林靖愉/吳焜裕 開課學院：公衛學院 開課系所︰公衛學系 考試日期（年月日）︰2012/06/21 考試時限（分鐘）：100分鐘 是否需發放獎勵金：是 （如未明確表示，則不予發放） 試題 : <IN CLASS> 1. Enzymes and receptors are proteins. However, both act differently and play different roles in biologic functions. Please compare the differences between enzymes and receptors. 2. Please use "Simple Receptor Occupancy Model" to explain what parameters affect potency and efficacy of a xenobiotic. 3. Please give an example to demostrate cellular signaling involving both electrical and chemical events and describe the example. 4. Toxicologists believe that reactive metabolite formation is correlated with toxicity. What macromolecules may be affected and what possible biological effects may be caused by reactive metabolites? 5. To detect lipid peroxidation, we usually measure secondary lipid oxidation products. Please give two names of secondary lipid oxidation products. 6. What do reactive oxygen species(ROS) include? 7. A new herbicide used in farm is suspected to be harmful to aquatic organism. Please describe how the herbicide gets in different environmental media and influences aquatic organisms in detail. <TAKE HOME> Please search for the toxicological profile or related information of ractopamine and answer the following questions: 1. Use the half life to estimate how much of ractopamine can be excreted if 1 mg of ractopamine is ingested by a man(body weight 70 kg). 2. Use the information you collect to describe the potential uncertainty of the 2 available risk assessment report by US FDA and JECFA. --

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