课程名称︰环境与职业毒理学概论 课程性质︰领域必修 课程教师︰林靖愉/吴焜裕 开课学院：公卫学院 开课系所︰公卫学系 考试日期（年月日）︰2012/06/21 考试时限（分钟）：100分钟 是否需发放奖励金：是 （如未明确表示，则不予发放） 试题 : <IN CLASS> 1. Enzymes and receptors are proteins. However, both act differently and play different roles in biologic functions. Please compare the differences between enzymes and receptors. 2. Please use "Simple Receptor Occupancy Model" to explain what parameters affect potency and efficacy of a xenobiotic. 3. Please give an example to demostrate cellular signaling involving both electrical and chemical events and describe the example. 4. Toxicologists believe that reactive metabolite formation is correlated with toxicity. What macromolecules may be affected and what possible biological effects may be caused by reactive metabolites? 5. To detect lipid peroxidation, we usually measure secondary lipid oxidation products. Please give two names of secondary lipid oxidation products. 6. What do reactive oxygen species(ROS) include? 7. A new herbicide used in farm is suspected to be harmful to aquatic organism. Please describe how the herbicide gets in different environmental media and influences aquatic organisms in detail. <TAKE HOME> Please search for the toxicological profile or related information of ractopamine and answer the following questions: 1. Use the half life to estimate how much of ractopamine can be excreted if 1 mg of ractopamine is ingested by a man(body weight 70 kg). 2. Use the information you collect to describe the potential uncertainty of the 2 available risk assessment report by US FDA and JECFA. --

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