課程名稱︰環境與職業毒理學概論 課程性質︰環職衛領域必修 課程教師︰林靖愉 開課學院：公共衛生學院 開課系所︰公共衛生學系 考試日期（年月日）︰101.04.19 考試時限（分鐘）：120 是否需發放獎勵金：是 （如未明確表示，則不予發放） 試題 : 1. What are differences between toxicants and drugs? Please give an example to demostrate that a chemical can be a drug and toxicant. 2. Toxicant A is a weak acid(pKa=4). Once it is in intestinal content(pH=6), is absorption of toxicant A favored or not? 3. Pick two route of exposure and list advantages and disadvantages of each. 4. Toxicant C and D have different degree of serum protein binding. The percentage of toxicant C and toxicant D binding to serum protein are 30% and 60%, respectively. Which toxicant(C or D) have a shorter half-life? Why? 5. (i)Mike intends to know the amount of BPA that people may expose. Could you please suggest him two ways to answer his question? (ii)Mike has found out that the amount of BPA in the body is very different among individuals. Please tell him four possible reasons to explain this finding. ╲ ╱ ╲ ╱ ╱╲ ╳ ╱╲ ╱ ╲╲ ╱ ╲ ╱ ╲╲ ╱ ╲╲╱ ╲╱ ╲╲ ｜｜ ｜ ｜｜ ｜ ｜｜ ｜ ｜｜ ｜ ｜｜ ｜ ｜｜ ｜ ╱╲ ╱╱ ╲ ╱╱╲ ╱ ╲ ╱╱ ╲ ╱╱ ╲ HO ╲╱ ╲╱ OH 註: Bisphenol A (畫的有點大...請多包涵= = ) 6. Please list three names of PhaseⅠ enzymes and three names of PhaseⅡ enzymes. 7. In the Rate Theory, what are the factors which contribute to peak broadening? Please illustrate your answers. 8. There are four steps involved to make a mass spectrometer produce mass spectra? Please briefly discuss your answers. --

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