课程名称︰环境与职业毒理学概论 课程性质︰环职卫领域必修 课程教师︰林靖愉 开课学院：公共卫生学院 开课系所︰公共卫生学系 考试日期（年月日）︰101.04.19 考试时限（分钟）：120 是否需发放奖励金：是 （如未明确表示，则不予发放） 试题 : 1. What are differences between toxicants and drugs? Please give an example to demostrate that a chemical can be a drug and toxicant. 2. Toxicant A is a weak acid(pKa=4). Once it is in intestinal content(pH=6), is absorption of toxicant A favored or not? 3. Pick two route of exposure and list advantages and disadvantages of each. 4. Toxicant C and D have different degree of serum protein binding. The percentage of toxicant C and toxicant D binding to serum protein are 30% and 60%, respectively. Which toxicant(C or D) have a shorter half-life? Why? 5. (i)Mike intends to know the amount of BPA that people may expose. Could you please suggest him two ways to answer his question? (ii)Mike has found out that the amount of BPA in the body is very different among individuals. Please tell him four possible reasons to explain this finding. ╲ ╱ ╲ ╱ ╱╲ ╳ ╱╲ ╱ ╲╲ ╱ ╲ ╱ ╲╲ ╱ ╲╲╱ ╲╱ ╲╲ ｜｜ ｜ ｜｜ ｜ ｜｜ ｜ ｜｜ ｜ ｜｜ ｜ ｜｜ ｜ ╱╲ ╱╱ ╲ ╱╱╲ ╱ ╲ ╱╱ ╲ ╱╱ ╲ HO ╲╱ ╲╱ OH 注: Bisphenol A (画的有点大...请多包涵= = ) 6. Please list three names of PhaseⅠ enzymes and three names of PhaseⅡ enzymes. 7. In the Rate Theory, what are the factors which contribute to peak broadening? Please illustrate your answers. 8. There are four steps involved to make a mass spectrometer produce mass spectra? Please briefly discuss your answers. --

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