主講人：洪宗乾 博士 (國立成功大學 統計學系) 題　目：Optimal in silico target gene deletion through nonlinear programming for genetic engineering 摘　要：The in silico target gene deletion problem will be discussed.The state-of-the-art of this problem for in silico genetic engineering will be reviewed. I will present an integer programming solution to the problem based on discrete dynamical system models for gene regulatory networks. Such a model can be obtained through a least squares method from observed dynamical system trajectories. I will show that this integer programming problem is NP-hard and can be reformulated into a nonlinear programming problem with fewer decision variables. Then, an algorithm, GKONP, is introduced to solve the nonlinear programming. The efficiency and accuracy of GKONP is discussed through comparing with the exhaustive approach. The results are applied to modify yeast pheromone pathways so as to control cell fusion of two mating haploid yeast cells. 日　期：99年11月3日(星期三) 14:30～15:30 地　點：本校數學館527教室（嘉義縣民雄鄉大學路168號） 茶　會：14:00～14:30於數學館四樓409室舉行 --

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