Nature 450, 497-502 (22 November 2007 Derivation of embryonic stem (ES) cells genetically identical to a patient by somatic cell nuclear transfer (SCNT) holds the potential to cure or alleviate the symptoms of many degenerative diseases while circumventing concerns regarding rejection by the host immune system. 由於不必擔心自體免疫的問題 大家對利用核轉移製成幹細胞治療或減緩退化性疾病有很高的期待 However, the concept has only been achieved in the mouse, whereas inefficient reprogramming and poor embryonic development characterizes the results obtained in primates. 可惜現在只有老鼠做得出來這種幹細胞 靈長類成功的例子還沒出現 Here, we used a modified SCNT approach to produce rhesus macaque blastocysts from adult skin fibroblasts, and successfully isolated two ES cell lines from these embryos. DNA analysis confirmed that nuclear DNA was identical to donor somatic cells and that mitochondrial DNA originated from oocytes. Both cell lines exhibited normal ES cell morphology, expressed key stem-cell markers, were transcriptionally similar to control ES cells and differentiated into multiple cell types in vitro and in vivo. Our results represent successful nuclear reprogramming of adult somatic cells into pluripotent ES cells and demonstrate proof-of-concept for therapeutic cloning in primates. 我們很榮幸的在這邊跟大家炫耀 我們用皮膚的fibroblasts做出兩株幹細胞株 雖然你們一定很忌妒但是我們已經確定那是幹細胞了 -- 美國人做出來的 有錢真好 --

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