From: http://news.sina.com.tw/global/sinacn/cn/2007-02-23/16493472351.shtml 日本利用活細菌長期保存資料 北京新浪網 (2007-02-23 16:49) 　　新華網東京2月23日電 日本慶應大學一個研究小組最近開發出一種可長期保存資 料的新技術：利用活細菌替代磁片和光盤等存儲媒介，從而將資料保存數百年甚至數 千年時間。 　　據日本《朝日新聞》21日報導，生物用以保存遺傳資訊的ＤＮＡ其實也是一種記 憶媒介。通過基因重組技術，人們可將人為資料記錄在某些生物的ＤＮＡ上。不過， 由於ＤＮＡ在上一代傳給下一代的過程中可能發生序列變化，它所保存的資料容易發 生缺損。 　　研究小組在枯草菌ＤＮＡ的4個地方用不同方式保存了相同內容的資料，以便在 其ＤＮＡ序列發生變化和破損的情況下，仍能使資料被復原。電腦演示結果表明，即 使細菌『更新換代』，資料仍可保存數百年甚至數千年。 　　研究小組說，這項利用細菌存儲資料的技術比光盤或硬盤更適合長期保存資料。 朝日新聞 連結 生きた細菌にデータを保存　慶應などのチームが開發 (日文) http://www.asahi.com/national/update/0221/TKY200702210105.html 日經新聞 連結 バクテリアを記錄媒体に？　慶大が技術 (日文) http://www.nikkei.co.jp/news/main/20070220AT1G2002Z20022007.html 原始論文： http://pubs.acs.org/cgi-bin/abstract.cgi/bipret/asap/abs/bp060261y.html Biotechnol. Prog., ASAP Article 10.1021/bp060261y S8756-7938(06)00261-X Web Release Date: January 25, 2007 Copyright (c) 2007 American Chemical Society and American Institute of Chemical Engineers Alignment-Based Approach for Durable Data Storage into Living Organisms Nozomu Yachie, Kazuhide Sekiyama, Junichi Sugahara, Yoshiaki Ohashi,* and Masaru Tomita Institute for Advanced Biosciences, Keio University, 403-1 Nipponkoku, Daihoji, Tsuruoka, 997-0017 Yamagata, Japan; Bioinformatics Program, Graduate School of Media and Governance, Keio University, 5322 Endo, Fujisawa, 252-8520 Kanagawa, Japan; Department of Environmental Information, Keio University, 5322 Endo, Fujisawa, 252-8520 Kanagawa, Japan; and Human Metabolome Technologies, Inc., 246-2 Mizukami, Kakuganji, Tsuruoka, 997-0052 Yamagata, Japan Received August 28, 2006. Accepted December 18, 2006. Abstract: The practical realization of DNA data storage is a major scientific goal. Here we introduce a simple, flexible, and robust data storage and retrieval method based on sequence alignment of the genomic DNA of living organisms. Duplicated data encoded by different oligonucleotide sequences was inserted redundantly into multiple loci of the Bacillus subtilis genome. Multiple alignment of the bit data sequences decoded by B. subtilis genome sequences enabled the retrieval of stable and compact data without the need for template DNA, parity checks, or error-correcting algorithms. Combined with the computational simulation of data retrieval from mutated message DNA, a practical use of this alignment-based method is discussed. --

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