--------------------------------------------------------------------------- 041022 --------------------------------------------------------------------------- SPECIAL ISSUE: Genes in Action --------------------------------------------------------------------------- Genes in Action: Introduction to special issue -------------------- Solving Gene Expression Barbara R. Jasny and Leslie Roberts http://www.sciencemag.org/cgi/content/summary/306/5696/629?etoc p. 629 Genes in Action: News -------------------- Getting the Noise Out of Gene Arrays Eliot Marshall http://www.sciencemag.org/cgi/content/summary/306/5696/630?etoc p. 630 Searching for the Genome's Second Code Elizabeth Pennisi http://www.sciencemag.org/cgi/content/summary/306/5696/632?etoc p. 632 A Fast and Furious Hunt for Gene Regulators Elizabeth Pennisi http://www.sciencemag.org/cgi/content/summary/306/5696/635?etoc p. 635 Genes in Action: Viewpoint -------------------- The ENCODE (ENCyclopedia Of DNA Elements) Project The ENCODE Project Consortium http://www.sciencemag.org/cgi/content/abstract/306/5696/636?etoc p. 636 Systems Biology and New Technologies Enable Predictive and Preventative Medicine Leroy Hood, James R. Heath, Michael E. Phelps, and Biaoyang Lin http://www.sciencemag.org/cgi/content/abstract/306/5696/640?etoc p. 640 Gene Order and Dynamic Domains Steven T. Kosak and Mark Groudine http://www.sciencemag.org/cgi/content/abstract/306/5696/644?etoc p. 644 Genes in Action: Review -------------------- Cis-Acting Regulatory Variation in the Human Genome Tomi Pastinen and Thomas J. Hudson http://www.sciencemag.org/cgi/content/abstract/306/5696/647?etoc p. 647 --------------------------------------------------------------------------- RESEARCH --------------------------------------------------------------------------- This Week in Science -------------------- http://www.sciencemag.org/content/vol306/issue5696/twis.shtml p. 571 Editors' Choice: Highlights of the recent literature -------------------- http://www.sciencemag.org/content/vol306/issue5696/twil.shtml p. 577 Research Articles -------------------- A Gene Expression Map for the Euchromatic Genome of Drosophila melanogaster Viktor Stolc, Zareen Gauhar, Christopher Mason, Gabor Halasz, Marinus F. van Batenburg, Scott A. Rifkin, Sujun Hua, Tine Herreman, Waraporn Tongprasit, Paolo Emilio Barbano, Harmen J. Bussemaker, and Kevin P. White http://www.sciencemag.org/cgi/content/abstract/306/5696/655?etoc p. 655 Brevia -------------------- A Precocial Avian Embryo from the Lower Cretaceous of China Zhonghe Zhou and Fucheng Zhang http://www.sciencemag.org/cgi/content/abstract/306/5696/653?etoc p. 653 Reports -------------------- Quantum-to-Classical Transition with Single-Photon-Added Coherent States of Lig ht Alessandro Zavatta, Silvia Viciani, and Marco Bellini http://www.sciencemag.org/cgi/content/abstract/306/5696/660?etoc p. 660 Quantum State Transfer Between Matter and Light D. N. Matsukevich and A. Kuzmich http://www.sciencemag.org/cgi/content/abstract/306/5696/663?etoc p. 663 Electric Field Effect in Atomically Thin Carbon Films K. S. Novoselov, A. K. Geim, S. V. Morozov, D. Jiang, Y. Zhang, S. V. Dubonos, I. V. Grigorieva, and A. A. Firsov http://www.sciencemag.org/cgi/content/abstract/306/5696/666?etoc p. 666 Hydrated Electron Dynamics: From Clusters to Bulk A. E. Bragg, J. R. R. Verlet, A. Kammrath, O. Cheshnovsky, and D. M. Neumark http://www.sciencemag.org/cgi/content/abstract/306/5696/669?etoc p. 669 Electrons in Finite-Sized Water Cavities: Hydration Dynamics Observed in Real Time D. Hern Paik, I-Ren Lee, Ding-Shyue Yang, J. Spencer Baskin, and Ahmed H. Zewail http://www.sciencemag.org/cgi/content/abstract/306/5696/672?etoc p. 672 How Do Small Water Clusters Bind an Excess Electron? Nathan I. Hammer, Joong-Won Shin, Jeffrey M. Headrick, Eric G. Diken, Joseph R. Roscioli, Gary H. Weddle, and Mark A. Johnson http://www.sciencemag.org/cgi/content/abstract/306/5696/675?etoc p. 675 Reconstructing Past Climate from Noisy Data Hans von Storch, Eduardo Zorita, Julie M. Jones, Yegor Dimitriev, Fidel Gonzalez-Rouco, and Simon F. B. Tett http://www.sciencemag.org/cgi/content/abstract/306/5696/679?etoc p. 679 Mycobacterial Ku and Ligase Proteins Constitute a Two-Component NHEJ Repair Mac hine Marina Della, Phillip L. Palmbos, Hui-Min Tseng, Louise M. Tonkin, James M. Daley, Leana M. Topper, Robert S. Pitcher, Alan E. Tomkinson, Thomas E. Wilson, and Aidan J. Doherty http://www.sciencemag.org/cgi/content/abstract/306/5696/683?etoc p. 683 Elemental and Redox Analysis of Single Bacterial Cells by X-ray Microbeam Analysis Kenneth M. Kemner, Shelly D. Kelly, Barry Lai, Joerg Maser, Edward J. O'Loughlin, Deirdre Sholto-Douglas, Zhonghou Cai, Mark A. Schneegurt, Charles F. Kulpa, Jr., and Kenneth H. Nealson http://www.sciencemag.org/cgi/content/abstract/306/5696/686?etoc p. 686 A Chromosome 21 Critical Region Does Not Cause Specific Down Syndrome Phenotypes L. E. Olson, J. T. Richtsmeier, J. Leszl, and R. H. Reeves http://www.sciencemag.org/cgi/content/abstract/306/5696/687?etoc p. 687 In Silico Genetics: Identification of a Functional Element Regulating H2-E{alpha} Gene Expression Guochun Liao, Jianmei Wang, Jingshu Guo, John Allard, Janet Cheng, Anh Ng, Steve Shafer, Anne Puech, John D. McPherson, Dorothee Foernzler, Gary Peltz, and Jonathan Usuka http://www.sciencemag.org/cgi/content/abstract/306/5696/690?etoc p. 690 The PP2A-Associated Protein {alpha}4 Is an Essential Inhibitor of Apoptosis Mei Kong, Casey J. Fox, James Mu, Laura Solt, Anne Xu, Ryan M. Cinalli, Morris J. Birnbaum, Tullia Lindsten, and Craig B. Thompson http://www.sciencemag.org/cgi/content/abstract/306/5696/695?etoc p. 695 A Network of Control Mediated by Regulator of Calcium/Calmodulin-Dependent Signaling S. V. Rakhilin, P. A. Olson, A. Nishi, N. N. Starkova, A. A. Fienberg, A. C. Nairn, D. J. Surmeier, and P. Greengard http://www.sciencemag.org/cgi/content/abstract/306/5696/698?etoc p. 698 Plant Cuticular Lipid Export Requires an ABC Transporter Jamie A. Pighin, Huanquan Zheng, Laura J. Balakshin, Ian P. Goodman, Tamara L. Western, Reinhard Jetter, Ljerka Kunst, and A. Lacey Samuels http://www.sciencemag.org/cgi/content/abstract/306/5696/702?etoc p. 702 Oscillations in NF-{kappa}B Signaling Control the Dynamics of Gene Expression D. E. Nelson, A. E. C. Ihekwaba, M. Elliott, J. R. Johnson, C. A. Gibney, B. E. Foreman, G. Nelson, V. See, C. A. Horton, D. G. Spiller, S. W. Edwards, H. P. McDowell, J. F. Unitt, E. Sullivan, R. Grimley, N. Benson, D. Broomhead, D. B. Kell, and M. R. H. White http://www.sciencemag.org/cgi/content/abstract/306/5696/704?etoc p. 704 Technical Comments -------------------- Comment on "Bedout: A Possible End-Permian Impact Crater Offshore of Northwestern Australia" Andrew Glikson http://www.sciencemag.org/cgi/content/full/306/5696/613b?etoc p. 613 Response to Comment on "Bedout: A Possible End-Permian Impact Crater Offshore of Northwestern Australia" L. Becker, R. J. Poreda, A. R. Basu, K. O. Pope, T. M. Harrison, C. Nicholson, and R. Iasky http://www.sciencemag.org/cgi/content/full/306/5696/613c?etoc p. 613 --------------------------------------------------------------------------- SCIENCE'S COMMENTARY --------------------------------------------------------------------------- Editorial -------------------- Genomics and Drug Toxicity Peter G. Lord and Thomas Papoian http://www.sciencemag.org/cgi/content/summary/306/5696/575?etoc p. 575 Letters -------------------- This Week's Letters http://www.sciencemag.org/cgi/content/summary/306/5696/609a?etoc p. 609 Another Question for Bush and Kerry http://www.sciencemag.org/cgi/content/full/306/5696/609b?etoc p. 609 Struggling to Attend U.S. Meetings http://www.sciencemag.org/cgi/content/full/306/5696/609c?etoc p. 609 Is Bedout an Impact Crater? Take 1 http://www.sciencemag.org/cgi/content/full/306/5696/609d?etoc p. 609 Is Bedout an Impact Crater? Take 2 http://www.sciencemag.org/cgi/content/full/306/5696/610?etoc p. 610 The Next Step for Kennewick Man http://www.sciencemag.org/cgi/content/full/306/5696/612?etoc p. 612 CORRECTIONS AND CLARIFICATIONS http://www.sciencemag.org/cgi/content/full/306/5696/613a?etoc p. 613 Policy Forum -------------------- NUCLEAR SAFETY: Brazil's Nuclear Puzzle Liz Palmer and Gary Milhollin http://www.sciencemag.org/cgi/content/summary/306/5696/617?etoc p. 617 Books -------------------- PHILOSOPHY OF BIOLOGY: A Centenarian's Summary Matthias Glaubrecht http://www.sciencemag.org/cgi/content/summary/306/5696/614?etoc p. 614 FICTION: Of Politics and Particle Physics Jay M. Pasachoff http://www.sciencemag.org/cgi/content/summary/306/5696/615?etoc p. 615 Books Received p. 615 Perspectives -------------------- CHEMISTRY: A Fresh Look at Electron Hydration Kenneth D. Jordan http://www.sciencemag.org/cgi/content/summary/306/5696/618?etoc p. 618 GENETICS: The Critical Region in Trisomy 21 David L. Nelson and Richard A. Gibbs http://www.sciencemag.org/cgi/content/summary/306/5696/619?etoc p. 619 CLIMATE: The Real Color of Climate Change? Timothy J. Osborn and Keith R. Briffa http://www.sciencemag.org/cgi/content/summary/306/5696/621?etoc p. 621 PLANT BIOLOGY: A Plant ABC Transporter Takes the Lotus Seat Burkhard Schulz and Wolf B. Frommer http://www.sciencemag.org/cgi/content/summary/306/5696/622?etoc p. 622 CHEMISTRY: Enhanced: Redesigning Genetics Steven A. Benner http://www.sciencemag.org/cgi/content/summary/306/5696/625?etoc p. 625 --------------------------------------------------------------------------- NEWS --------------------------------------------------------------------------- News of the Week -------------------- BIOETHICS: Stem Cell Researchers Mull Ideas for Self-Regulation http://www.sciencemag.org/cgi/content/summary/306/5696/586?etoc p. 586 MALARIA: A Complex New Vaccine Shows Promise http://www.sciencemag.org/cgi/content/summary/306/5696/587a?etoc p. 587 PLANETARY SCIENCE: Flipped Switch Sealed the Fate of Genesis Spacecraft http://www.sciencemag.org/cgi/content/summary/306/5696/587b?etoc p. 587 CANADA: Martin Backs Science Academy http://www.sciencemag.org/cgi/content/summary/306/5696/589a?etoc p. 589 BIOTERRORISM AND THE COURTS: Butler Appeals Conviction, Risking Longer Sentence http://www.sciencemag.org/cgi/content/summary/306/5696/590a?etoc p. 590 INFECTIOUS DISEASES: Bird Flu Infected 1000, Dutch Researchers Say http://www.sciencemag.org/cgi/content/summary/306/5696/590b?etoc p. 590 BIOCONTAINMENT: 1918 Flu Experiments Spark Concerns About Biosafety http://www.sciencemag.org/cgi/content/summary/306/5696/591a?etoc p. 591 GENERAL RELATIVITY: Swiveling Satellites See Earth's Relativistic Wake http://www.sciencemag.org/cgi/content/summary/306/5696/592a?etoc p. 592 MEDICINE: Metabolic Defects Tied to Mitochondrial Gene http://www.sciencemag.org/cgi/content/summary/306/5696/592b?etoc p. 592 PHYSICS: Researchers Build Quantum Info Bank By Writing on the Clouds http://www.sciencemag.org/cgi/content/summary/306/5696/593?etoc p. 593 NATIONAL INSTITUTES OF HEALTH: Male Sweep of New Award Raises Questions of Bias http://www.sciencemag.org/cgi/content/summary/306/5696/595a?etoc p. 595 NATIONAL SCIENCE FOUNDATION: End of Cost Sharing Could Boost Competition http://www.sciencemag.org/cgi/content/summary/306/5696/595b?etoc p. 595 News Focus -------------------- IMMUNOLOGY: Policing the Immune System http://www.sciencemag.org/cgi/content/summary/306/5696/596?etoc p. 596 CLIMATE CHANGE: A Few Good Climate Shifters http://www.sciencemag.org/cgi/content/summary/306/5696/599?etoc p. 599 BEHAVIORAL SCIENCE: NIMH Takes a New Tack, Upsetting Behavioral Researchers http://www.sciencemag.org/cgi/content/summary/306/5696/602?etoc p. 602 INFECTIOUS DISEASES: Hawaii Girds Itself for Arrival of West Nile Virus http://www.sciencemag.org/cgi/content/summary/306/5696/603?etoc p. 603 NetWatch -------------------- http://www.sciencemag.org/content/vol306/issue5696/netwatch.shtml p. 585 ScienceScope -------------------- http://www.sciencemag.org/content/vol306/issue5696/s-scope.shtml p. 589 Random Samples -------------------- http://www.sciencemag.org/content/vol306/issue5696/r-samples.shtml p. 605 --------------------------------------------------------------------------- DEPARTMENTS --------------------------------------------------------------------------- Products & Materials -------------------- NEW PRODUCTS p. 709 _______________________________________________________________________ Copyright (c) 2004 by the American Association for the Advancement of Science. 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