※ 引述《andrewjliu (JOE平)》之铭言： : 各位Pharmacy板友好, : 我现在药学三年级~ : 我有个朋友情绪不太稳 : 去看精神科...怀疑是schizophrenia....囧rz : 他爸爸打电话问我医生开的药(小大三 其实懂得真的很少..) : ABILIFY (aripiprazole) : http://www.abilify.com : 虽然最近药理有教...可是我也搞不清楚这类药算那类 Atypical (or 2nd generation) antipsychotic. : 但是上课教...antipsychotic drug的副作用:EPS...Parkinson症状..anticholinergic : 感觉还满恐怖的.. 而且我朋友也没很严重 : 想请问有人知道这个药吗? : 不知道Abilify造成的副作用是不是reversible....@o@ : 拜托各位厉害的板众给我些资讯...谢谢m(_ _)m 药学生要开始练习自己找资料罗! 光看药厂的网站资料是不太够的, 建议可以透过图书馆连到Micromedix or AHFS Drug Information, 这两个对药物不良反应/副作用都有蛮详细的描述, (AHFS也有平装的红皮书, 图书馆应该会有.) 以下摘自AHFS (不好意思没时间翻译), The American Psychiatric Association (APA) considers certain atypical antipsychotic agents (i.e., aripiprazole, olanzapine, quetiapine, risperidone, ziprasidone) first-line drugs for the management of the acute phase of schizophrenia (including first psychotic episodes), principally because of the decreased risk of adverse extrapyramidal effects and tardive dyskinesia, with the understanding that the relative advantages, disadvantages, and cost-effectiveness of conventional and atypical antipsychotic agents remain controversial. (以下是Phenothizine的作用,Abilify作用应该一样但发生机率较小) Extrapyramidal reactions can be divided into acute and chronic reactions. Acute extrapyramidal reactions are signs and symptoms that develop during the first days and weeks of phenothiazine or other antipsychotic agent administration, are dose related, and are reversible upon dosage reduction or discontinuance of the drug. However, severe extrapyramidal reactions have reportedly occurred even at relatively low dosages. Chronic extrapyramidal reactions are signs and symptoms that occur following months or years of therapy with phenothiazines or other antipsychotic drugs, are not clearly dose related, and may persist following drug discontinuance. Dystonic reactions and feelings of motor restlessness occur most frequently in young patients, especially those with acute infections or severe dehydration, whereas parkinsonian signs and symptoms predominate in geriatric patients, especially those with brain damage. Dystonic reactions usually occur rather early during treatment, but the incidence of feelings of motor restlessness and parkinsonian signs and symptoms is greater after several weeks of therapy. 以上这只是一小部分的资料而已, 希望有回答到你的问题, 建议你有空去查micromedix or AHFS, 会有比较完整详细的资料, 回答这类问题时, 不要只看副作用, 也要看看药效, 才能给病人一个平衡的解释, 不然病人吓都吓死了, 自己乱停药才糟糕... 另外黄字有标到, 年轻人比较可能有dystonic reactions, 要避免的方法就是多喝水,避免脱水的情况 记得跟你朋友提罗! --

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