治病良药还是癌症元凶？马兜铃酸「导致肝癌」事件调查 美国《科学─转化医学》杂志10月中旬发表一篇封面论文，题为《台湾及更广亚洲地区的 肝癌与马兜铃酸及其衍生物广泛相关》，杂志编辑以「一种草药的黑暗面」为题推荐了这 篇论文。而这篇论文的结论是：马兜铃酸与肝癌之间存在「决定性关联」。 基於对全世界共计1400多个肝癌样本的分析，论文指出，含马兜铃酸的草药在亚洲尤其台 湾被广泛使用，但并没有直接说马兜铃酸是当地肝癌高发的原因。 针对这篇论文的内容，国家食品药品监督管理总局新闻发言人回应称，根据流行病学大样 本、大资料分析，我国肝癌患者主要由乙肝病毒感染引起。是否与马兜铃酸有直接关系， 尚无直接有力的资料支撑。 食药监总局新闻发言人指出，虽然马兜铃酸与肝癌的直接相关性尚无直接有力资料支撑， 但马兜铃酸具有明显肾毒性，可造成肾小管功能受损，甚至存在引发肾癌的风险 http://www.storm.mg/article/353822 The dark side of an herbal medicine Aristolochic acid, an herbal compound found in many traditional medicines, had been previously linked to kidney failure, as well as cancers of the urinary tract. Because of these known toxicities, herbs containing this compound have been restricted or banned in some countries, but it is still available on the internet and in alternate formulations. By analyzing numerous samples from Taiwan and other countries in Asia and elsewhere, Ng et al. demonstrated the effects of aristolochic acid in hepatocellular carcinoma, a much more common tumor type. The authors showed that the use of this drug remains widespread in Asia and particularly in Taiwan, and that it appears to increase the risk of multiple different cancer types. http://stm.sciencemag.org/content/9/412/eaan6446 卫福部/中药制剂中马兜铃酸成分之调查 本次所抽查的99件检体其处方名及件数如表一，经高效液相层析法分析，结果只有1件 处方标示含有木防己的检体检出马兜铃酸I成分，检测值为4.94 ppm（4.94 μg/g）， 推测应为药材搀杂少量广防己所造成，一般市售制剂之处方应使用粉防己、汉防己、 川木通、木香等不含马兜铃酸成分之药材 https://imgur.com/PBiGjsh https://www.fda.gov.tw/TC/PublishHistoryB.aspx?pn=57 --

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