欢迎参加！ http://ntu-bst.blogspot.tw/2013/09/101-pm-1320-1520-201.html 时间: 2013/ 10/ 01 (周二）下午 13:20-15:20 地点: 台湾大学 共同教学馆 201 教室 演讲人: 周 芷 院士 (不连续基因发现者。美国国家科学院院士。阿拉巴马 大学分子遗传学教授。大学联考三类组榜首。台大生化科技学系系友） 报名网址: http://goo.gl/MkQrQy 周芷教授维基百科介绍: http://tinyurl.com/LC20131001 演讲主题: Achilles heel – Strategy to Stop Human Papillomaviruses in Their Tracks 摘要: Human papillomaviruses (HPVs) are a large family of prevalent pathogens, causing hyperproliferation of cutaneous and mucosal epithelia, commonly known as warts. Persistent Infections by the high-risk HPV-16, HPV-18 and closely related types can progress to high grade lesions and cancers, such as cervical, penile, anal, and laryngeal cancers, as well as a fraction of other head and neck cancers. Prophylactic vaccines effectively prevent infections by 4 virus types but do not cure pre-existing infections. Therapeutic agents are urgently needed. Genetic studies of these viruses are hampered because these viruses cannot be propagated in conventional cell cultures. Rather, the productive phase depends on proper squamous differentiation. We have developed an organotypic skin culture system of primary human keratinocytes to recapitulate a robust viral life cycle, permitting genetic analyses of viral genes. Combined with our investigation of the mechanisms that regulate viral DNA replication and amplification, we have identified Achilles heel to control virus infection. --

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