作者littledragon (Bouncer)
看板Biotech
标题[期刊]PPARdelta与血管加压素协调VSMC的衰老作用
时间Wed Nov 21 18:11:52 2012
http://www.jbc.org/content/286/52/44585.full.pdf+html
[PPARδ Coordinates Angiotensin II-induced Senescence in Vascular Smooth
Muscle Cells through PTEN-mediated Inhibition of Superoxide Generation]
J. Biol. Chem. 2011 286: 44585-44593. First Published on November 9, 2011,
PPAR delta为ligand activated nuclear receptor
近年被指出可以维持血管的恒定
而这篇期刊指出PPAR delta可藉由up-reglate PTEN
来减弱Angiotensin II造成血管平滑肌细胞衰老的作用
并且维持PI3K/Akt的调节
如果knockdown PTEN则会废止上述的那些作用
而由Angiotensin II做引发的ROS也会再度增加
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※ 编辑: littledragon 来自: 140.122.152.97 (11/21 18:12)
1F：推 Rxxxxxxxxx:sent 11/21 18:14
谢谢您
※ 编辑: littledragon 来自: 140.122.152.97 (11/21 18:17)