※ [本文转录自 Biology 看板] 作者: senlin (seize) 站内: Biology 标题: A Cell paper from Taiwan 时间: Fri Mar 23 05:58:20 2007 Cell, Vol 128, 1205-1217, 23 March 2007 A Map of Olfactory Representation in the Drosophila Mushroom Body Hui-Hao Lin,1,2 Jason Sih-Yu Lai,1,2 An-Lun Chin,1,2 Yung-Chang Chen,3,4 and Ann-Shyn Chiang1,2,3,5,6, 1 Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC 2 Department of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC 3 Brain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC 4 Engineering and System Science group, Department of Electrical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC 5 Department of Life Science, National Central University, Taoyuan 32001, Taiwan, ROC 6 Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA Corresponding author Ann-Shyn Chiang [email protected] Summary Neural coding for olfactory sensory stimuli has been mapped near completion in the Drosophila first-order center, but little is known in the higher brain centers. Here, we report that the antenna lobe (AL) spatial map is transformed further in the calyx of the mushroom body (MB), an essential olfactory associated learning center, by stereotypic connections with projection neurons (PNs). We found that Kenyon cell (KC) dendrites are segregated into 17 complementary domains according to their neuroblast clonal origins and birth orders. Aligning the PN axonal map with the KC dendritic map and ultrastructural observation suggest a positional ordering such that inputs from the different AL glomeruli have distinct representations in the MB calyx, and these representations might synapse on functionally distinct KCs. Our data suggest that olfactory coding at the AL is decoded in the MB and then transferred via distinct lobes to separate higher brain centers. http://www.cell.com/content/article/abstract?uid=PIIS0092867407003170 ※ 编辑: senlin 来自: 146.189.54.60 (03/23 05:59) --

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