SCIENCE, Volume 306, Issue 5704, Breakthrough of the Year dated December 17 2004, is now available at: http://www.sciencemag.org/content/vol306/issue5704/?etoc A plain-text copy of the table of contents has been appended below. If you no longer wish to receive these messages, you may modify your "Contents Awareness" profile at: http://www.sciencemag.org/cgi/etoc In addition, this week's Science Express papers are now available at: http://www.sciencexpress.org These selected papers are published rapidly online soon after acceptance. They will appear in print in several weeks. The abstracts are freely available. The full text is available free to AAAS members or for a nominal fee ($10) to nonmembers. To sign up for a weekly email listing of Science express papers, go to: http://www.sciencemag.org/cgi/etoc For research and policy news, posted each weekday by Science's news team, http://www.sciencenow.org --------------------------------------------------------------------------- --------------------------------------------------------------------------- SPECIAL ISSUE: Breakthrough of the Year --------------------------------------------------------------------------- Breakthrough of the Year: News -------------------- BREAKTHROUGH OF THE YEAR: On Mars, a Second Chance for Life Richard A. Kerr http://www.sciencemag.org/cgi/content/summary/306/5704/2010?etoc p. 2010 Doing Science Remotely Elizabeth Pennisi and Richard A. Kerr http://www.sciencemag.org/cgi/content/summary/306/5704/2011?etoc p. 2011 BREAKTHROUGH OF THE YEAR: Scorecard 2003 http://www.sciencemag.org/cgi/content/summary/306/5704/2012?etoc p. 2012 BREAKTHROUGH OF THE YEAR: The Runners-Up http://www.sciencemag.org/cgi/content/summary/306/5704/2013?etoc p. 2013 BREAKTHROUGH OF THE YEAR: Areas to Watch in 2005 http://www.sciencemag.org/cgi/content/summary/306/5704/2014?etoc p. 2014 BREAKTHROUGH OF THE YEAR: Breakdown of the Year: The Unwritten Contract http://www.sciencemag.org/cgi/content/summary/306/5704/2015?etoc p. 2015 BREAKTHROUGH OF THE YEAR: Avian Influenza: Catastrophe Waiting in the Wings? http://www.sciencemag.org/cgi/content/summary/306/5704/2016?etoc p. 2016 --------------------------------------------------------------------------- RESEARCH --------------------------------------------------------------------------- This Week in Science -------------------- http://www.sciencemag.org/content/vol306/issue5704/twis.shtml p. 1997 Editors' Choice: Highlights of the recent literature -------------------- http://www.sciencemag.org/content/vol306/issue5704/twil.shtml p. 2003 Research Articles -------------------- United Time-Frequency Spectroscopy for Dynamics and Global Structure Adela Marian, Matthew C. Stowe, John R. Lawall, Daniel Felinto, and Jun Ye http://www.sciencemag.org/cgi/content/abstract/306/5704/2063?etoc p. 2063 Brevia -------------------- Human Amygdala Responsivity to Masked Fearful Eye Whites Paul J. Whalen, Jerome Kagan, Robert G. Cook, F. Caroline Davis, Hackjin Kim, Sara Polis, Donald G. McLaren, Leah H. Somerville, Ashly A. McLean, Jeffrey S. Maxwell, and Tom Johnstone http://www.sciencemag.org/cgi/content/abstract/306/5704/2061?etoc p. 2061 Reports -------------------- Building Programmable Jigsaw Puzzles with RNA Arkadiusz Chworos, Isil Severcan, Alexey Y. Koyfman, Patrick Weinkam, Emin Oroudjev, Helen G. Hansma, and Luc Jaeger http://www.sciencemag.org/cgi/content/abstract/306/5704/2068?etoc p. 2068 Translation of DNA Signals into Polymer Assembly Instructions Shiping Liao and Nadrian C. Seeman http://www.sciencemag.org/cgi/content/abstract/306/5704/2072?etoc p. 2072 A Late-Transition Metal Oxo Complex: K7Na9[O=PtIV(H2O)L2], L = [PW9O34]9- http://www.sciencemag.org/cgi/content/abstract/306/5704/2074?etoc p. 2074 Clues from Fe Isotope Variations on the Origin of Early Archean BIFs from Greenland http://www.sciencemag.org/cgi/content/abstract/306/5704/2077?etoc p. 2077 Darwinian Selection on a Selfing Locus http://www.sciencemag.org/cgi/content/abstract/306/5704/2081?etoc p. 2081 Acetylation by Tip60 Is Required for Selective Histone Variant Exchange at DNA Lesions http://www.sciencemag.org/cgi/content/abstract/306/5704/2084?etoc p. 2084 Mammalian Tissue Oxygen Levels Modulate Iron-Regulatory Protein Activities in Vivo Esther G. Meyron-Holtz, Manik C. Ghosh, and Tracey A. Rouault http://www.sciencemag.org/cgi/content/abstract/306/5704/2087?etoc p. 2087 Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization Elizabeta Nemeth, Marie S. Tuttle, Julie Powelson, Michael B. Vaughn, Adriana Donovan, Diane McVey Ward, Tomas Ganz, and Jerry Kaplan http://www.sciencemag.org/cgi/content/abstract/306/5704/2090?etoc p. 2090 Hemoxygenase-2 Is an Oxygen Sensor for a Calcium-Sensitive Potassium Channel Sandile E. J. Williams, Phillippa Wootton, Helen S. Mason, Jonathan Bould, David E. Iles, Daniela Riccardi, Chris Peers, and Paul J. Kemp http://www.sciencemag.org/cgi/content/abstract/306/5704/2093?etoc p. 2093 Discovery of a Major D-Loop Replication Origin Reveals Two Modes of Human mtDNA Synthesis Jennifer Fish, Nicola Raule, and Giuseppe Attardi http://www.sciencemag.org/cgi/content/abstract/306/5704/2098?etoc p. 2098 Phosphorylation of Proteins by Inositol Pyrophosphates Adolfo Saiardi, Rashna Bhandari, Adam C. Resnick, Adele M. Snowman, and Solomon H. Snyder http://www.sciencemag.org/cgi/content/abstract/306/5704/2101?etoc p. 2101 Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway http://www.sciencemag.org/cgi/content/abstract/306/5704/2105?etoc p. 2105 Cofolding Organizes Alfalfa Mosaic Virus RNA and Coat Protein for Replication Laura M. Guogas, David J. Filman, James M. Hogle, and Lee Gehrke http://www.sciencemag.org/cgi/content/abstract/306/5704/2108?etoc p. 2108 bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNS http://www.sciencemag.org/cgi/content/abstract/306/5704/2111?etoc p. 2111 Technical Comments -------------------- Comment on "Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch" James T. Stivers http://www.sciencemag.org/cgi/content/full/306/5704/2042b?etoc p. 2042 Response to Comment on "Uracil DNA Glycosylase Activity Is Dispensable for immunoglobulin Class Switch" N. A. Begum and T. Honjo http://www.sciencemag.org/cgi/content/full/306/5704/2042c?etoc p. 2042 --------------------------------------------------------------------------- SCIENCE'S COMMENTARY --------------------------------------------------------------------------- Editorial -------------------- Breakthrough of the Year Donald Kennedy http://www.sciencemag.org/cgi/content/summary/306/5704/2001?etoc p. 2001 Letters -------------------- This Week's Letters http://www.sciencemag.org/cgi/content/summary/306/5704/2039a?etoc p. 2039 Psychiatric Treatment for Great Apes? http://www.sciencemag.org/cgi/content/full/306/5704/2039b?etoc p. 2039 Stopping the Spread of Drug-Resistant Malaria http://www.sciencemag.org/cgi/content/full/306/5704/2039c?etoc p. 2039 The Bush Administration and Climate Change http://www.sciencemag.org/cgi/content/full/306/5704/2041?etoc p. 2041 CORRECTIONS AND CLARIFICATIONS http://www.sciencemag.org/cgi/content/full/306/5704/2042a?etoc p. 2042 Policy Forum -------------------- EDUCATION: Risks and Rewards of an Interdisciplinary Research Path Diana Rhoten and Andrew Parker http://www.sciencemag.org/cgi/content/summary/306/5704/2046?etoc p. 2046 Books -------------------- HISTORY OF SCIENCE: Bragg Reflections John Meurig Thomas http://www.sciencemag.org/cgi/content/summary/306/5704/2043?etoc p. 2043 Browsings http://www.sciencemag.org/cgi/content/full/306/5704/2044?etoc p. 2044 BIOMECHANICS: Optimized for Chewing Natalia Rybczynski http://www.sciencemag.org/cgi/content/summary/306/5704/2045?etoc p. 2045 Books Received p. 2045 Perspectives -------------------- ANTHROPOLOGY: The Astonishing Micropygmies Jared Diamond http://www.sciencemag.org/cgi/content/summary/306/5704/2047?etoc p. 2047 MATERIALS SCIENCE: Nucleic Acid Nanotechnology Hao Yan http://www.sciencemag.org/cgi/content/summary/306/5704/2048?etoc p. 2048 CELL BIOLOGY: Oxygen Sensing: It's a Gas! Toshinori Hoshi and Sukhamay Lahiri http://www.sciencemag.org/cgi/content/summary/306/5704/2050?etoc p. 2050 CELL BIOLOGY: " Pumping" Iron: The Proteins Ernest Beutler http://www.sciencemag.org/cgi/content/summary/306/5704/2051?etoc p. 2051 SIGNAL TRANSDUCTION: Unexpected Mediators of Protein Phosphorylation John D. York and Tony Hunter http://www.sciencemag.org/cgi/content/summary/306/5704/2053?etoc p. 2053 CHEMISTRY: Enhanced: Whence Molecular Electronics? Amar H. Flood, J. Fraser Stoddart, David W. Steuerman, and James R. Heath http://www.sciencemag.org/cgi/content/summary/306/5704/2055?etoc p. 2055 Review -------------------- Silicon Device Scaling to the Sub-10-nm Regime Meikei Ieong, Bruce Doris, Jakub Kedzierski, Ken Rim, and Min Yang http://www.sciencemag.org/cgi/content/abstract/306/5704/2057?etoc p. 2057 --------------------------------------------------------------------------- NEWS --------------------------------------------------------------------------- News of the Week -------------------- NASA: O'Keefe to Go, But Hubble Remains a Battleground http://www.sciencemag.org/cgi/content/summary/306/5704/2018a?etoc p. 2018 DEPARTMENT OF ENERGY: Nominee Scores Cabinet Hat Trick http://www.sciencemag.org/cgi/content/summary/306/5704/2018b?etoc p. 2018 BUSH CABINET: EPA's Leavitt Tapped for Health Post http://www.sciencemag.org/cgi/content/summary/306/5704/2019?etoc p. 2019 QUANTUM PHYSICS: The Quantum Perfect Storm http://www.sciencemag.org/cgi/content/summary/306/5704/2021a?etoc p. 2021 SEISMOLOGY: Eavesdropping on Faults to Anticipate Their Next Move http://www.sciencemag.org/cgi/content/summary/306/5704/2022a?etoc p. 2022 BIODEFENSE: Experts Warn Against Censoring Basic Science http://www.sciencemag.org/cgi/content/summary/306/5704/2022b?etoc p. 2022 NEUROSCIENCE: Mutant Gene Tied to Poor Serotonin Production and Depression http://www.sciencemag.org/cgi/content/summary/306/5704/2023a?etoc p. 2023 JAPANESE UNIVERSITIES: Junior Faculty Hope Name Change Will Lead to Greater Independence http://www.sciencemag.org/cgi/content/summary/306/5704/2025a?etoc p. 2025 INFLUENZA: WHO Adds More "1918" to Pandemic Predictions http://www.sciencemag.org/cgi/content/summary/306/5704/2025b?etoc p. 2025 News Focus -------------------- ARCHAEOLOGY: The Indus Script--Write or Wrong? http://www.sciencemag.org/cgi/content/summary/306/5704/2026?etoc p. 2026 ARCHAEOLOGY: Splendid Sewers, But Little Sculpture http://www.sciencemag.org/cgi/content/summary/306/5704/2027?etoc p. 2027 ARCHAEOLOGY: Outsider Revels in Breaking Academic Taboos http://www.sciencemag.org/cgi/content/summary/306/5704/2028?etoc p. 2028 RICHARD VILLEMS PROFILE: Cutting a Path in Genetics and International Diplomacy http://www.sciencemag.org/cgi/content/summary/306/5704/2030?etoc p. 2030 ACADEMIC CAREERS: Family Matters: Stopping Tenure Clock May Not Be Enough http://www.sciencemag.org/cgi/content/summary/306/5704/2031?etoc p. 2031 MATERIALS RESEARCH SOCIETY MEETING: Organic Solar Cells Playing Catch-Up http://www.sciencemag.org/cgi/content/summary/306/5704/2034a?etoc p. 2034 MATERIALS RESEARCH SOCIETY MEETING: Can Organics Take On Flash Memory? http://www.sciencemag.org/cgi/content/summary/306/5704/2034b?etoc p. 2034 MATERIALS RESEARCH SOCIETY MEETING: Protein Engineers Go for Gold http://www.sciencemag.org/cgi/content/summary/306/5704/2035a?etoc p. 2035 MATERIALS RESEARCH SOCIETY MEETING: Snapshots From the Meeting http://www.sciencemag.org/cgi/content/summary/306/5704/2035b?etoc p. 2035 NetWatch -------------------- http://www.sciencemag.org/content/vol306/issue5704/netwatch.shtml p. 2009 ScienceScope -------------------- http://www.sciencemag.org/content/vol306/issue5704/s-scope.shtml p. 2021 Random Samples -------------------- http://www.sciencemag.org/content/vol306/issue5704/r-samples.shtml p. 2036 --------------------------------------------------------------------------- DEPARTMENTS --------------------------------------------------------------------------- Products & Materials -------------------- NEW PRODUCTS p. 2116 --

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