作者starjuice (喝吧~ 歲月 乾杯!)
看板TransBioChem
標題Re: [生物] lection和selectin有什麼不同
時間Thu Jul 6 02:54:52 2006
※ 引述《BTWu (kian)》之銘言:
: 請問一下是否有人知道
: lectin 和selectin到底有什麼不同呢^^
Selectins 為表現在leukocytes、endothelial cells與platelets上的
carbohydrate-binding proteins,主要功能是調控leukocytes移動到各種組織。
分成L-selectin(CD62L),L指的就是leukocyte
E-selectin(CD62E),E指的是endothelial cells
P-selectin(CD62P),P指的是platelets
可以參考一下這個圖的說明
http://www.theses.ulaval.ca/2003/21038/21038027.jpg
Lectin
來源:
http://www.chem.qmul.ac.uk/iubmb/newsletter/misc/lectin.html
定義
A lectin is a sugar-binding protein of non-immune origin that
agglutinates cells or precipitates glycoconjugates.
Comments
1. A lectin molecule contains at least two sugar-binding sites;
sugar-binding proteins with a single site will not agglutinate
or precipitate structures that contain sugar residues, so are
not classified as lectins.
2. The specificity of a lectin is usually defined by the
monosaccharides or oligosaccharides that are best at inhibiting
the agglutination or precipitation the lectin causes.
3. Lectins occur in many types of organism; they may be soluble
or membrane-bound; they may be glycoproteins.
4. Sugar-specific enzymes, transport proteins and toxins may
qualify as lectins if they have, multiple sugar-binding sites.
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