作者BTWu (kian)
看板TransBioChem
標題Re: [生物] 生物問題
時間Wed Nov 9 11:49:10 2005
※ 引述《yiyan (陳金鋒你是最強的)》之銘言:
: 20 . Consider a protein that is made in the rough endoplasmic reticulum.
: You observe that when the synthesis of the protein is completed, the protein is located in the ER membrane.
: Where else in the cell might this protein be found?
: 1in the aqueous interior of a lysosome functioning as a digestive enzyme
: 2in the cytoplasm, functioning as an enzyme in carbohydrate synthesis
: 3embedded in the plasma membrane functioning in the transport of molecules
: into the cell
: 4in the internal space of the Golgi apparatus, being modified before the
: protein is excreted
: 5in a mitochondrion functioning in ATP synthesis
我覺得這題題目出的不好,如以原理來說明,
其實答案是1,3,4都是對的,
想知道為什麼,要先了解free ribosome 和bound ribosome的差別,
bound ribosome會經由SRP接到ER上(因為有一點點的,吾人稱之為RER)
將新生的protein注入ER內,至於文中所說的e synthesis of the protein is
completed是指在RER內folding 成功,但是別忘了,還有初級醣化以及脂化反應
這都是在ER內發生的,接下來在Golgi還有二級醣化和磷酸化的加成(所以4是對的),
磷酸化會使得protein形成lysosome(所以1是對的),至於無磷酸化的preotein
大部分會經由cytoskeleton運送到膜形成膜蛋白(3是對的),或是分泌出胞外。
而free ribosome.....所產生出來的protein是負責細胞質的反應,以及當作
胞內液的buffer維持穩定,也會提供mt 和葉綠体讓他們形光合作用和呼吸作用
看看囉,這是我第一次在此板回問題說^^
--
※ 發信站: 批踢踢實業坊(ptt.cc)
◆ From: 163.26.9.72