※ 引述《tiniwiel (tiniwiel)》之銘言： : ※ 引述《peter3752001 (手黑的腳白佑)》之銘言： : : 讀季瑋珠老師的那份講義 : : 有些問題 : : 請知道的同學或路過的學長姐 : : 幫忙解惑吧 : : 衛導不好念,但是要普救世人 : : 就要咬牙撐過去啊~~~(感冒中,喉嚨痛) : : 1.P.2中間左邊那張ppt : : literature retrieval and exclusion criteria是什麼意思? : : 2.P.4中間右邊那張"基本設計"的對照組 : : 下面寫說跟個案對照方法的對照不同 : : 是哪裡不同? : : : 3.同上頁右下 依照時間 : : 同時是怎麼對照? : : 歷史又是怎麼對照? : 我在網路上找到的資料...可以參考一下啦 : 雖然是英文的 但我覺得他解釋得滿清楚的 : historical control: : The results of treatment with the test drug : are compared with experience historically derived from the adequately : documented natural history of the disease or condition, or from the : results of active treatment, in comparable patients or populations. : Because historical control populations usually cannot be as well : assessed with respect to pertinent variables as can concurrent control : populations, historical control designs are usually reserved for special : circumstances. Examples include studies of diseases with high and : predictable mortality (for example, certain malignancies) and studies in : which the effect of the drug is self-evident (general anesthetics, drug : metabolism). : : 4.P.5左下 : : 納入跟排除條件在說什麼? : Inclusion and exclusion criteria are a means of establishing precision : in your cohort or case-control study. For example, you might suspect that : a new brand of insulin tablet is more effective than an existing brand, : but for some reason this seems to be true only for diabetic patients that : are not overweight by more than 10%. Your professional knowledge has : produced a "hunch" that has you well on your way to establishing inclusion : and exclusion criteria. : Inclusion criteria are the criteria for including a patient in the study, : and it is important that these criteria be clearly defined in an objective : manner, so that anyone involved in the study (or anyone attempting to : replicate the study) can reproduce patient inclusion decisions precisely. : In other words, can you write down the inclusion criteria so that anyone else : with professional knowledge similar to your own would include the same patients : you included? : The example above, of the new insulin tablet versus an existing one, could be : translated into an inclusion criteria by specifying the two drugs (e.g. brand : name, generic and manufacturer name, possibly even lot number). : Exclusion criteria are the criteria for excluding patients from the study. : From the example above, the 10% overweight criterion could serve as the basis : for a specific exclusion criteria statement. As in the case of inclusion : criteria, is your specification precise enough that someone with knowledge : similar to your own would exclude the same patients you choose to exclude? : : 5.P.6右上 : : 事件是最終的終點 : : 二分法則是叫硬性終點 : : 所以事件不等於硬性終點吧(是二分法才是)? : : 6.同上張 : : 設限資料跟存活分析是什麼? : : (雖然不會考這麼細,但是可不可以稍微講一下) 存活分析:事件/事件史資料(二分法 硬性終點)加上時間軸 就成為存活分析了吧 : : 7.Basic approaches是在講什麼的方法? 囧 : : 8.P.7右上 : : 何謂干擾因素? : : 為什麼說結果比流行病學研究可信? : : (那現在說的是什麼方法在跟流行病學研究比?) : : 9.同上頁中間左邊那張 : : 為什麼加入時間就變存活分析? 應該就可以畫曲線圖表示 在某一時間點個體的生死吧(此處的硬性終點應該是存活/死亡) : : 10.同上頁左下 : : Marginal是什麼意思? : : 11.P.8右上 : : 非標準實驗方法又稱準實驗方法??? : : 12.P.9 : : 實驗方法有很多種而藥物臨床試驗只是其中一種,對嗎? : : 實驗方法等不等於實驗流行病學? 請向阿湯哥借"公共衛生學" 今天看了裡面有實驗流病學的解釋喔 : : 問題頗多發現自己好像讀太細了~ : : 捉不到重點啊~ : 你真的讀的很細！！讓我發現自己很多地方都沒看清楚... : 呵呵～大家加油！！ 問題 第二頁左上outcomes in outcome management 是啥意思捏 --

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