課程名稱︰蛋白質化學與分子模擬 課程性質︰選修 課程教師︰楊健志 開課學院：生命科學院 開課系所︰生化科技學系 考試日期（年月日）︰2016/11/09 考試時限（分鐘）：120分鐘 試題 : 1. Please describe the principle of protein crystallization. 2. Please describe the principle of protein structure determination of x-ray crystallography. Also, why x-ray, but not other magnetic wavelengths, is used for atomic resolution determination of biomolecules? 3. Please describe the chemical properties of those biologically relevant metal ions. And how these properties related to their function in biology. 4. Please describe the structure features of the major secondary structure of proteins. 5. Please discuss the principles of protein evolution and the formation of protein domains, based on both the chemistry and biology aspects. And discuss how the identification of protein domains is related to the functional studies of protein. 6. Based on the literature PS1701 provided in Ceiba, please describe at least three protein folds in terms of their structure and function. (For example, acetylcholine esterase fold, immunoglobulin fold, alpha/beta hydrolase fold etc) (編按: 該檔案為Current Protocols in Protein Science (2004) Unit 17.1: Overview of Protein Structural and Functional Folds) 7. Please discuss the principles and general steps of homology modeling of protein. 8. Please derive the Michaelis-Menten equation for the kinetics analysis of enzymes. 9. Please distinguish steady-state kinetics and pre-steady-state enzyme kinetics. 10. Write a question which you ever wanted to ask in this class. (標準楊氏風格的問題) PS. 老師當天還叫大家多拿了張答案卷回去寫，把不會寫的題目查清楚後再寫得更詳細 (不知道是不是預設大家都會寫很少) (也不知道這怎麼算分就是) --

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