課程名稱︰生醫工程概論 課程性質︰選修 課程教師︰郭柏齡 開課學院：電機資訊學院 開課系所︰電機工程學系 考試日期（年月日）︰101/4/17 考試時限（分鐘）：180分鐘 試題 : Midterm 2012 1. A boy has a hard, painful, and growing mass occurring on his right leg noted for three months. A bony tumor is found on an x-ray image. The tumor is at the tibia bone close to right knee. Which of the following statement is the most common way to describe the location of the tumor in medical images: (A) The tumor is at the superior part of right tibia (B) The tumor is at the knee section of right tibia (C) The tumor is at the rostral part of right tibia (D) The tumor is at the proximal part of right tibia (E) The tumor is at the cranial part of right tibia 2. Two men were trapped in a mountain without any supplement for one week and were found by a rescue team. Suppose you are the leader of the team. The victims seem severely dehydrated and you decide to give them intra-venous body fluid supplement immediately. Which of the following is the right solution for an intra-venous body fluid supplement at this moment? (A) A liter of distilled water containing 110 mM sodium, 50 mM chloride, 10 mM lactate, and 130 mM calcium (B) A liter of distilled water containing 150 gm dextrose (L-glucose, molecularweight: 180 gm/mol) (C) A litter of distilled water containing 75 mM sodium, 75 mM chloride, 40 mM potassium, and 100 gm dextrose (D) A litter of distilled water containing 150 mM sodium, 50 mM chloride, and 100 mM potassium (E) A liter of distilled water containing 150 mM sodium, and 150 mM chloride 3. The following table shows concentrations of the major ions in a squid giant axon. ┌──┬──────┬──────────┬────────┬────────┐ │Ion │ Cytoplasm │Extracellular Fluid │ Ratio of │Nernst Potential│ │ │ (mM) │ (mM) │ Permeabilities │ (mV) │ ├──┼──────┼──────────┼────────┼────────┤ │K+ │ 400 │ 20 │ 1 │ -74 │ │Na+ │ 50 │ 440 │ 0.04 │ 55 │ │Cl- │ 52 │ 560 │ 0.45 │ -60 │ └──┴──────┴──────────┴────────┴────────┘ Note that the permeabilities are relative, that is P_K : P_Na : P_Cl, and not absolute. Data were recorded at 6.3℃, resulting in KT/q approximately equal to 25.3 mV. What events change the membrane potential during the depolarization and the repolarization phases of an action potential, respectively? Use the concept of the Nernst and Goldman equations and the information in the above table to justify your answer. 4. The following figure shows the result of an immunoassay. The y-axis shows the detected fluorescence intensity which is proportional to the amount of fluorescently labeled detection antibody. Explain why the analyte concentration has a negative correlation with the detected fluorescence intensity. http://imgur.com/ohM4agK 5. Identify the two parts, receptor and transducer, of the surface plasmon resonance (SPR) biosensor. 6. Suppose you want to design a blood pressure monitor that has a full dynamic range of 0~350 mmHg and a bandwidth of 0~100Hz. The transducer is a flexible diaphragm connected to four strain gauges as shown in the following figure. The system is calibrated with known values of fluid pressure and the full range of pressure (0~350 mmHg) corresponds linearly to ΔR = 0~0.5(Ω) http://imgur.com/N3eAkWL (A) What is the sensitivity of the transducer? (B) The transducer output will be connected to an isolation amplifier, followed by a low-pass filter. Explain the functions of these components. (C) Describe how to achieve an ideal resolution of 0.5 mmHg, given a 10-bit A/D converter which has an input range of -5V~5V. (D) Suppose you notice 60 Hz noise in the acquired signal and you decide to remove it with a digital notch filter. Use a sampling frequency of 240 Hz to simplify the calculations. Determine the values of zeros and poles you would use and derive the transfer function of your digital filter. Write down the final expression of the filter intime domain. Hint: useful equation Z[x(n - k)] = z^(-k) Z[x(n)] 7. Draw a general structure of a neuron in artificial neural networks and describe the relation between the input and the output of the neuron. --

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