作者fizeau (.)
看板EngTalk
標題[Ask ] Why would the anti-inflammatory drug cause ulcer
時間Thu Nov 27 22:47:37 2008
I've read a news article about Barbara Bush, a former first lady of
the United States, who underwent a surgery to fix her perforated
duodenum ulcer.
It's suspected that the anti-inflammatory drug could cause this--
uncommon but not unheard of.
Why is that? What is the likely mechanism of it?
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1F：推 Bigfatty73:most NSAIDS (Non Steroidal Anti Inflammatory Drugs) 11/27 23:20
2F：→ Bigfatty73:are COX (Cyclooxygenase) inhibitors 11/27 23:21
3F：→ Bigfatty73:There are 2 dominant COX forms (human) COX1; COX2 11/27 23:21
4F：→ Bigfatty73:in short, COX1 is responsible for blood/mucosal 11/27 23:24
5F：→ Bigfatty73:regulation, COX2 is for Inflammation 11/27 23:25
6F：→ Bigfatty73:------------------------------------------- 11/27 23:28
7F：→ Bigfatty73:So why not just inhibit COX2 ? 11/27 23:29
8F：→ Bigfatty73:at 2004, a COX2 specific(~30 fold)inhibitor Vioxx 11/27 23:31
9F：→ Bigfatty73:was recalled from the market, no patients had ulcer 11/27 23:33
10F：→ Bigfatty73:but almost half suffered myocardial infarction... 11/27 23:34
11F：推 Bigfatty73:Merck, was hurt bad 11/27 23:37
12F：→ formec:the more you are saying , the more vague I fell. XD 11/27 23:52
13F：推 Bigfatty73:okay my wrong. The most popluar anti inflammatory 11/27 23:54
14F：→ Bigfatty73:is catagorized as NSAIDS 11/27 23:55
15F：→ Bigfatty73:It reduces both COX1 and COX2 in the body ^drugs 11/27 23:56
16F：→ Bigfatty73:If you need Pain relief, you only need to stop COX2 11/27 23:57
17F：→ Bigfatty73:Instead, COX1 is affected as well, causing stomach- 11/27 23:58
18F：→ Bigfatty73:problems 11/27 23:59
19F：推 wnwangster:chemistry always does the trick better than count- 11/28 01:00
20F：→ wnwangster:ing sheeps. 11/28 01:00