【職缺名稱】 碩士級專任研究助理 1人 【徵才單位】 國立陽明大學 生命科學系暨基因體科學研究所 范明基老師實驗室 簡介: Deciphering the genetic instructions that establish the pattern of neuronal differentiation during development is one of the keys to understand the complexity of the adult brain. My laboratory has adopted developmental approaches and molecular biology tools to gain more insight about how mammalian nervous system organizes and functions through analysis of novel neural genes. By subtractive hybridization, we found that expression of Prtg, a member of immunoglobulin family, is very abundant in the E7.75 ~ E9.5 mouse neural tube but disappears after E10.5. Using the P19 cell line and chick embryo as neural differentiation models, we demonstrated that Prtg prevents precocious neuronal differentiation. We identified ERdj3 as a ligand for Prtg. Furthermore, ERdj3 prevents precocious neuronal differentiation through activation of Prtg (J. Neurosci. 30 (2010) 4428-4439). We will further investigate effects of ERdj3/Prtg in vivo and its signaling pathway. 【工作地址】 國立陽明大學 【工作內容】 動物實驗 (breeding mice, embryo dissection, etc.)、 分生相關實驗 (PCR, in situ hybridization, etc.)、 細胞培養 【徵才條件】 生物相關研究所畢業、具動物實驗經驗 【薪資待遇】 比照國科會規定 碩士級35000/月 【聯絡方式】 意者請e-mail履歷至 [email protected] 信件標題請註明〔應徵研究助理〕 【其他備註】 --

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