The Physical Biology Group of Prof. Dr. Ernst H. K. Stelzer at the Goethe University in Frankfurt am Main invites PhD students interested in high resolution, light sheet-based fluorescence microscopy We seek to employ an enthusiastic, highly motivated physics or bioinformatics student holding, or about to obtain a diploma or an equivalent degree, with strong interests in the modern three-dimensional microscopy, and image reconstruction processing and visualization. The specific project we are interested in combines the high resolution structured illumination technique with light sheet-based fluorescence microscopy. Structured illumination microscopy is one of the high resolution techniques nowadays that achieves a resolution of less than 100 nm. Light sheet-based fluorescence microscopy is a three-dimensional microscopy that reduces phototoxicity by two to four orders of magnitude and allows live and long-term imaging. The project concentrates on a novel microscopic system. Our aim is to implement the high resolution, low photo-toxicity, and live imaging microscope and to apply it with biological samples, e.g. three-dimensional and live imaging of microtubule asters. The successful applicant will learn the physics behind advanced light microscopy technologies and contribute to building the new microscope, developing the image reconstruction program, and applying the microscope with biological samples. Additionally, we also evaluate the combination of light sheet-based fluorescence microscopy with other high resolution techniques such as photoactivated localization microscopy. The group of Prof. Stelzer (www.physikalischebiologie.de) is part of the Buchmann Institute for Molecular Life Science (www.bmls.de). It constitutes an interdisciplinary team of chemists, biologists, biotechnologists, mathematicians, and physicists. The laboratory is equipped with state of the art facilities for cell culture and molecular biology, as well as with advanced fluorescence microscopy equipment, including light sheet-based fluorescence microscopy. The group is particularly interested in observing threedimensional processes of cellular systems as a function of time. Therefore, we are pursuing for better microscopic technique as well as providing physical explanation to address biological questions. It is very interesting to work in such an interdisciplinary team because, for example, to understand the need from a biologist, then to develop a new technique and test it immediately; or to discuss physical explanation of biological phenomena with biologist. There is full of learning and surprise to do science here. The position is currently available to commence as soon as possible. For now, the contract will be limited till 31.12.2014. The selection process will take place as soon as possible until the position is filled. Full consideration is given to all applications received by 31.03.2013. Come on, give your life a twist and contact [email protected] --

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