※ 引述《LEEDFITH (Mirror)》之铭言： : 刚刚去哺乳协会查risk 0 : http://www.e-lactancia.org/product/322 : 但去PDR : http://ppt.cc/VsRT : 又说建议不要 : 看了仿单也不行 在妈宝版学到的一个资料库 美国国家医学资料库(National Library of Medicine，NLM) 中的药物与哺乳的资料库“Lactmed”http://goo.gl/LKO5xh 我把查到的资料贴上 ------------------------------------------------------------------------ Cetirizine ------------------------------------------------------------------------ CASRN: 83881-51-0 For other data, click on the Table of Contents # Drug Levels and Effects: > Summary of Use during Lactation: Small occasional doses of cetirizine are probably acceptable during breastfeeding. Larger doses or more prolonged use may cause drowsiness and other effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The British Society for Allergy and Clinical Immunology recommends cetirizine at its lowest dose as a preferred choice if an antihistamine is required during breastfeeding.[1] # Drug Levels: > Maternal Levels. Relevant published information was not found as of the revision date. > Infant Levels. Relevant published information was not found as of the revision date. # Effects in Breastfed Infants: In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention.[2] A woman who was nursing (extent not stated) her newborn infant was treated for pemphigus with oral prednisolone 25 mg daily, with the dosage increased over 2 weeks to 60 mg daily. She was also taking cetirizine 10 mg daily and topical betamethasone 0.1% twice daily to the lesions. Because of a poor response, the betamethasone was changed to clobetasol propionate ointment 0.05%. She continued breastfeeding throughout treatment and her infant was developing normally at 8 weeks of age and beyond.[3] # Possible Effects on Lactation: Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[4][5] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[4] Whether lower oral doses of cetirizine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed. # Alternate Drugs to Consider: Desloratadine, Fexofenadine, Loratadine References: 1. Powell RJ, Du Toit GL, Siddique N et al. BSACI guidelines for the management of chronic urticaria and angio-oedema. Clin Exp Allergy. 2007;37:631-50. PMID: 17456211 2. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418 3. Westermann L, Hugel R, Meier M et al. Glucocorticosteroid-resistant pemphigoid gestationis: successful treatment with adjuvant immunoadsorption. J Dermatol. 2012;39:168-71. PMID: 22379622 4. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731 5. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996 -- 像遇到一阵风的遇到你 意外的艳丽 风吹不熄满天的星斗 却卷起满天风沙 天昏地暗的只感觉你 --

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