以下来自micromedex Cisplatin-Fluorouracil Y-Site Compatible Admixture Incompatible Syringe Compatible Admixture Detail： Cisplatin 0.2 mg/mL Fluorouracil 1 mg/mL Incompatible In Normal saline- Sodium chloride 0.9% Physical Compatibility: Physically compatible. No haze or particulate formation, color change, or gas evolution. Chemical Stability: Chemically unstable. About 10% cisplatin loss occurred in 90 minutes and about 25 to 30% loss occurred in 3 to 4 hours. No fluorouracil loss occurred within the study period. Storage: Room temperature of 24 to 26 °C exposed to fluorescent light and protected from light. Study Period: Up to 24 hours. Method: Visual observation and stability-indicating HPLC analysis of drug concentrations. Container: Polyvinyl chloride (PVC) bags. Ref:Stewart CF, Fleming RA: Compatibility of cisplatin and fluorouracil in 0.9% sodium chloride injection Am J Hosp Pharm: 1990 47: 1373-7 ------------------------------------------------------------------------------ Cisplatin 0.5 mg/mL Fluorouracil 10 mg/mL Incompatible In Normal saline- Sodium chloride 0.9% Physical Compatibility: Physically compatible. No haze or particulate formation, color change, or gas evolution. Chemical Stability: Chemically unstable. About 10% cisplatin loss occurred in 90 minutes and about 25 to 30% loss occurred in 3 to 4 hours. No fluorouracil loss occurred within the study period. Storage: Room temperature of 24 to 26 °C exposed to fluorescent light and protected from light. Study Period: Up to 24 hours. Method: Visual observation Container: Polyvinyl chloride (PVC) bags. Ref:Stewart CF, Fleming RA: Compatibility of cisplatin and fluorouracil in 0.9% sodium chloride injection Am J Hosp Pharm: 1990 47: 1373-7 ----------------------------------------------------------------------------- Cisplatin 0.5 mg/mL Fluorouracil 10 mg/mL Incompatible In Normal saline- Sodium chloride 0.9% Physical Compatibility: Not reported. Chemical Stability: Chemically unstable. About 80% loss of cisplatin occurred in 24 hours. Storage: Room temperature protected from light. Study Period: 15 days. Method: HPLC analysis of drug concentrations. Container: Polyvinyl chloride (PVC) plastic bags. Ref:Lokich J, Anderson N, Bern M, et al: Combined floxuridine and cisplatin in a fourteen day infusion Cancer: 1988 62: 2309-12 ※ 引述《wylscott (林 佳树)》之铭言： : 最近有遇到这个例子 : 虽然我和几位药师觉得怪怪的 : 因为Cisplatin是酸性 : 而5-Fu是硷性 : 但是查了Micromedex : 并没有Drug-Drug interaction : 不过医师坚持这样用我也没办法 : 请问有其他在医院的同仁们有听过这种用法吗？ : 这样药效会不会减弱呢？ : 会的话 : 请问你们认为影响的机转是什麽？ : 麻烦解惑一下谢谢～ --

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