想请问一下大家这样合不合理 调剂61题 下列药品，何者与葡萄柚汁并服使用时，不需顾虑交互作用？ (A) felodipine (B) lovastatin (c) cyclosporine (D) diazepam 我在applied 94-6的Table 94-3 上面写到CYP3A4的 Neonatal Substrate 包括Acetaminophen, alfentanil, carbamazepine, cisapride, diazepam, erythromycin, lidocaine, midazolam, t heophylline, verapamil, R-warfarin 在known developmental pattern 提到 上述CYP3A4的 Neonatal Substrate 为Low activity in the first month of life, with approach toward adult level by 6-12 months of postnatal age. Pharmacokinetic data for CYP3A4 subtrates suggest that adult activity may be exceeded between 1 and 4 years of age. Activity then progressively declines, reaching adult level at the conclusion of puberty. 药治 第1题 下列药品中，何者可改善2 岁以下婴幼儿的鼻炎症状，且较不会造成中枢神经抑制的 副作用？ (A) hydroxyzine(B) dexchlorpheniramine(c) loratadine(D) cetirizine Loratadine和 cetirizine都是第二代抗组织胺 且中枢神经副作用接为low to none 而且Applied 25-14的 Table 25-3上面有写到 Cetirizine 可用在12~23 mo: 2.5mg QD or 2.5 mg Q 12 hr 6~11mo: 2.5mg QD Infants <6 mo: Safe and effective use has not been established. Loratadine: Child <2 yr: Safe and effective use has not been established. 此外Cetirizine 在Anticholinergic 方面的副作用为low to none 而Loratadine在Anticholinergic 方面的副作用为 low 所以我认为这题应该选D也可以 不知道大家觉得怎麽样?? --

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