前文恕删 根据Mandell, Bennett, & Dolin: Principles and Practice of Infectious Diseases, 6th ed. 节录自chapter 29 Glycopeptides (Vancomycin and Teicoplanin), Streptogramins (Quinupristin-Dalfopristin), and Lipopeptides (Daptomycin) ...A considerable number of studies have found that the bactericidal activity of vancomycin is concentration independent once a concentration of four or five times the MIC for the organism is reached, and that the pharmacodynamic parameters that best express its activity are the time that the vancomycin concentration is greater than the MIC and the 24-hour area under the concentration-time curve (AUC)/MIC ratio. The in vitro postantibiotic effect of vancomycin against staphylococci and enterococci has been described mostly as of short duration. Reference: Lowdin E, Odenholt I, Cars O: In vitro studies of pharmacodynamic properties of vancomycin against Staphylococcus aureus and Staphylococcus epidermidis. Antimicrob Agents Chemother 1998; 42:2739-2744. vancomycin的效果是属於time-dependent killing 虽然它也有一些postantibiotic effect 但效果很短 因此基本上还是属於time-dependent 典型的concentration-dependent killing Abx例如aminoglycosides即是 --

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