※ 引述《rexking (rex)》之铭言： : 医学一66 : 第66题A选项: : 皮细胞会分泌TGF-B、PGE2等”抗发炎”物质来调控共生菌引起的免疫反应。 : PGE2作用在不同受器，会产生抗发炎及导致发炎两种不同结果，作用在受器EP1~3会加强 : 发炎反应，作用在受器EP4则会抑制发炎。因此认为第66题A选项上皮细胞会分泌TGF-B : 、PGE2等”抗发炎”物质来调控共生菌引起的免疫反应。有争议。 : 因为PGE2的作用取决於作用的受器，无法直接将其分类为发炎物质或抗发炎物质，而且在 : 大部分生理药理学的用书里，多强调其为发炎的生理及药理效用，而且许多药物机转 : (如NSAID)也都建立在抑制PGE2，能够抗发炎。因此认为此题选项A有争议，此题四个选项 : 皆有错误，建议送分。 : 以下附上参考资料来源 : http://jpet.aspetjournals.org/content/319/3/1096.abstract : 希望有任何意见都可以一起提出来讨论~ : 感谢~ 如果加上这个不知道好不好? 根据Kuby Immunology 第五版Chapter 15 (P349)内文提到: Metabolism of arachidonic acid by the cyclooxygenase pathway produces prostaglandins and thromboxanes. Different prostaglandins are produced by different cells: monocytes and macrophages produce large quantities of PGE2 and PGF2; neutrophils produce moderate amounts of PGE2; mast cells produce PGD2. Prostaglandins have diverse physiological effects, including increased vascular permeability, increased vascular dilation, and induction of neutrophil chemotaxis. The thromboxanes cause platelet aggregation and constriction of blood vessels. 依照此文字叙述, 又加上Robbins对发炎的定义: Acute Inflammation Acute inflammation is a rapid response to an injurious agent that serves to deliver mediators of host defense-leukocytes and plasma proteins-to the site of injury. Acute inflammation has three major components: (1) alterations in vascular caliber that lead to an increase in blood flow; (2) structural changes in the microvasculature that permit plasma proteins and leukocytes to leave the circulation; and (3) emigration of the leukocytes from the microcirculation, their accumulation in the focus of injury, and their activation to eliminate the offending agent (Fig. 2-2). 故推论PGE2不是一种抗发炎物质, 因此本题A选项应为错误 建议此题送分 --

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