※ 引述《chihuahua (chihuahua)》之铭言： : [申覆] 医学六　31 : 答案: B.怀孕前服用叶酸及多种维生素,怀孕後接受高层次超音波检查 : 这答案好像已经把etiology设定为:Folic acid deficiency : 其它的etiology也包括了:Genetic factors : -->那麽D也应该是答案之一 前文恕删 Neural-tube defects are classical examples of multifactorial inheritance. Their development is influenced by environment, diet, physiological abnormalities such as hyperthermia or hyperglycemia, teratogen exposure, family history, ethnic origin, fetal gender, amnionic fluid nutrients, and various genes. The fact that certain defects are associated with specific risk factors suggests that many genes are likely to be involved in neural-tube development. For example, those associated with type 1 diabetes mellitus are likely to be cranial or cervical-thoracic defects; hyperthermia has been associated with anencephaly; and valproic acid exposure with lumbosacral defects (Becerra and colleagues, 1990; Hunter, 1984; Lindhout and associates, 1992). Although Hibbard and Smithells (1965) postulated more than 30 years ago that abnormal folate metabolism was responsible for many neural-tube malformations, a specific gene defect only recently has been implicated. A thermolabile variant of the enzyme 5,10-methylene tetrahydrofolate reductase (MTHFR), which plays a key role in folate metabolism, has been associated with neural-tube defects. 资料来源：国考指定用书 Cunningham, Gary; Leveno, Kenneth J.; Gilstrap, Larry C.. Williams Obstetrics (22nd Edition). Blacklick, OH, USA: McGraw-Hill Companies, The, 2005. p 302. http://site.ebrary.com/lib/taimedical/Doc?id=10176686&ppg=318 Copyright c 2005. McGraw-Hill Companies, The. All rights reserved. 申覆理由：由课文可知，已有确定的gene异常导致其叶酸代谢出问题，并致neural-tube defects，故D选项夫妻接受染色体检查应该也是可行的选项。 建议B、D均给分。 不知道这样的佐证有没有比较有力= = --

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