Williams 21 edition p.857 .........Approximately 50 to 60 percent of early spontanoeus abortions are associated with chromosomal anomaly of the conceptus. ................ 所以应该可以建议做染色检查 D应该可以选 手边没有22版的Williams 不知道有没有人有新版Williams? 另外题干中有提到acrania 不知道有没有人有Nelson可以查一下是否acrania跟chromosome有无关系? 这样立论就更清楚了 ※ 引述《chihuahua (chihuahua)》之铭言： : [申覆] 医学六　31 : 答案: B.怀孕前服用叶酸及多种维生素,怀孕後接受高层次超音波检查 : 这答案好像已经把etiology设定为:Folic acid deficiency : 其它的etiology也包括了:Genetic factors : -->那麽D也应该是答案之一 : Genetic factors — A genetic factor is suggested by the observations that : NTDs have a high concordance rate in monozygotic twins, are more frequent : among siblings, and are more common in females compared to males [9]. : In addition, there is a high prevalence of karyotypic abnormalities among : fetuses with NTDs, especially in the presence of other congenital anomalies. : For example, a large study evaluating the frequency of chromosomal : abnormalities in pregnancies with fetal NTDs found these abnormalities in : 6.5 percent of affected cases (4/167 fetuses with an isolated NTD and 9/33 : fetuses with a NTD and associated anomalies) [10]. A second series reported : a similar rate (7 percent) of chromosomal abnormalities in fetuses with NTDs : [11]. Trisomy 18 was the most common aneuploidy in both series. These data : support the use of fetal karyotyping as an aid in diagnostic : evaluation and recurrence risk counseling. : 资料来源: Uptodate.com - Anencephaly and encephalocele : 建议B,D皆给分 : 覆议的请推文 谢谢 --

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